https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&feed=atom&action=history
Cisplatin - Revision history
2024-03-29T00:25:09Z
Revision history for this page on the wiki
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https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=5353&oldid=prev
MDolinar at 13:26, 4 February 2011
2011-02-04T13:26:58Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:26, 4 February 2011</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin spada v skupino alkilirajočih citostatičnih učinkovin. Poleg njega sta v tej skupini tudi karboplatin in oksaliplatin. Cisplatin uporabljamo pri zdravljenju različnih tipov raka, kot so sarkomi, pljučni rak, rak jajčnikov, limfni in tumorjev zarodnih celic. Aplicirajo ga kot intravenske infuzije za zdravljenje malignih obolenj. Cisplatin se je uporablja za kombinirano terapijo<del style="font-weight: bold; text-decoration: none;">. Uporablja se ga </del>tudi <del style="font-weight: bold; text-decoration: none;">kot </del>preventivno zdravljenje. <sup>[[Cisplatin#Viri|[1]]]</sup></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin spada v skupino alkilirajočih citostatičnih učinkovin. Poleg njega sta v tej skupini tudi <ins style="font-weight: bold; text-decoration: none;">[[</ins>karboplatin<ins style="font-weight: bold; text-decoration: none;">]] </ins>in oksaliplatin. Cisplatin uporabljamo pri zdravljenju različnih tipov raka, kot so sarkomi, pljučni rak, rak jajčnikov, limfni in tumorjev zarodnih celic. Aplicirajo ga kot intravenske infuzije za zdravljenje malignih obolenj. Cisplatin se je uporablja za kombinirano terapijo<ins style="font-weight: bold; text-decoration: none;">, pa </ins>tudi <ins style="font-weight: bold; text-decoration: none;">za </ins>preventivno zdravljenje. <sup>[[Cisplatin#Viri|[1]]]</sup></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Molekula deluje in vivo, <del style="font-weight: bold; text-decoration: none;">tako </del>da zamreži molekule DNA in na ta način preprečuje delitev celic. V vodnem okolju telesa se kloridni atom v cisplatinu lahko zamenja s hidroksilno skupino <br /> ((PtCl)(H<sub>2</sub>O)(NH<sub>3</sub>)<sup>2+</sup>)in kasneje z delom DNA. Vodni <del style="font-weight: bold; text-decoration: none;">ligant </del>v tej molekuli se z lahkoto poveže <del style="font-weight: bold; text-decoration: none;">na </del>bazo v DNA, predvsem z gvaninom. Nastane ((PtCl(gvanin-DNA)NH<sub>3</sub>)<sup>2+</sup>). Platina povzroči premreženje dveh baz, pri tem se odstrani še drugi kloridni ligand. Poškodbi DNA sledi celična smrt (apoptoza)<del style="font-weight: bold; text-decoration: none;">. </del>[http://www.youtube.com/watch?v=QfXc9gIt_hM <del style="font-weight: bold; text-decoration: none;">(Video </del>delovanja cisplatina)<del style="font-weight: bold; text-decoration: none;">]</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Molekula deluje <ins style="font-weight: bold; text-decoration: none;">''</ins>in vivo<ins style="font-weight: bold; text-decoration: none;">'' tako</ins>, da zamreži molekule DNA in na ta način preprečuje delitev celic. V vodnem okolju telesa se kloridni atom v cisplatinu lahko zamenja s hidroksilno skupino <br /> ((PtCl)(H<sub>2</sub>O)(NH<sub>3</sub>)<sup>2+</sup>)in kasneje z delom DNA. Vodni <ins style="font-weight: bold; text-decoration: none;">ligand </ins>v tej molekuli se z lahkoto poveže <ins style="font-weight: bold; text-decoration: none;">z </ins>bazo v DNA, predvsem z gvaninom. Nastane ((PtCl(gvanin-DNA)NH<sub>3</sub>)<sup>2+</sup>). Platina povzroči premreženje dveh baz, pri tem se odstrani še drugi kloridni ligand. Poškodbi DNA sledi celična smrt (apoptoza) <ins style="font-weight: bold; text-decoration: none;">(</ins>[http://www.youtube.com/watch?v=QfXc9gIt_hM <ins style="font-weight: bold; text-decoration: none;">video </ins>delovanja cisplatina<ins style="font-weight: bold; text-decoration: none;">]</ins>)<ins style="font-weight: bold; text-decoration: none;">.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Pri visoki koncentraciji klorida v krvi reakcija zamenjave ne poteče hitro. Če pa je koncentracija kloridov v krvi nizka, cisplatin reagira z drugimi proteini. To pa ni učinkovito pri uničevanju rakavih celic.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Pri visoki koncentraciji klorida v krvi reakcija zamenjave ne poteče hitro. Če pa je koncentracija kloridov v krvi nizka, cisplatin reagira z drugimi proteini. To pa ni učinkovito pri uničevanju rakavih celic.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Cisplatin povezuje DNA na različne načine in deluje pri celični delitvi mitozi. Poškodovan DNA vzpodbudi »popravni« DNA mehanizem. Vendar je obnova DNA nemogoča. </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Ugotovitev na rakavih celicah debelega črevesja: Apoptoza, ki je inducirana s strani cisplatina je odvisna od mitohondrijske serin-proteaze. Sprašujejo se, ali je ta mitohondrijska serin-proteaza prav tako učinkovita na drugih tkivih. <sup>[[Cisplatin#Viri|[3]]]</sup></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin <del style="font-weight: bold; text-decoration: none;">je bil prvič opisan leta 1845. Njegova struktura je bila natančno opisana leta 1893. Raziskave </del>na <del style="font-weight: bold; text-decoration: none;">cisplatinu je izvajal Rosenberg leta 1865</del>. <del style="font-weight: bold; text-decoration: none;">Prvič je bil cisplatin uporabljen za zdravljenje raka leta 1978</del>.<del style="font-weight: bold; text-decoration: none;"><sup>[[Cisplatin#Viri|[2]]]</sup></del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin <ins style="font-weight: bold; text-decoration: none;">povezuje DNA </ins>na <ins style="font-weight: bold; text-decoration: none;">različne načine in deluje pri celični delitvi mitozi</ins>. <ins style="font-weight: bold; text-decoration: none;">Poškodovana DNA vzpodbudi mehanizem popravljanja DNA, vseeno pa obnova DNA ni več mogoča</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt<del style="font-weight: bold; text-decoration: none;">. </del>[http://www.cisplatin.org/images/cisplatin.png <del style="font-weight: bold; text-decoration: none;">(Skica </del>molekule)<del style="font-weight: bold; text-decoration: none;">]</del>. Njena mol. masa je 300,05 g/mol.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Na rakavih celicah debelega črevesja so ugotovili, da je apoptoza, ki jo inducira cisplatin, odvisna od mitohondrijske serinske proteaze. Ni pa še jasno, ali je ta mitohondrijska serinska proteaza prav tako učinkovita v drugih tkivih. <sup>[[Cisplatin#Viri|[3]]]</sup></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Cisplatin je bil prvič opisan leta 1845, njegova natančna struktura pa leta 1893. Raziskave uporabe cisplatina v medicini je med prvimi izvajal Rosenberg leta 1965, prvič pa so ga uporabili za zdravljenje raka leta 1978.<sup>[[Cisplatin#Viri|[2]]]</sup></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt <ins style="font-weight: bold; text-decoration: none;">(</ins>[http://www.cisplatin.org/images/cisplatin.png <ins style="font-weight: bold; text-decoration: none;">skica </ins>molekule<ins style="font-weight: bold; text-decoration: none;">]</ins>). Njena mol. masa je 300,05 g/mol.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s cisplatinom]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s cisplatinom]</div></td></tr>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4880&oldid=prev
Natasa: /* Viri */
2010-12-12T22:57:06Z
<p><span dir="auto"><span class="autocomment">Viri</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:57, 12 December 2010</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function.htm Delovanje cisplatina]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function.htm Delovanje cisplatina]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* [http://books.google.si/books?id=Yii3zZRSb7cC&printsec=frontcover&dq=cisplatin&source=bl&ots=1xvu2n7yBg&sig=1r6VJhdzrEr8BIDmWNwMvxvoDM0&hl=sl&ei=H1IFTemUBZHqOYGlwaYB&sa=X&oi=book_result&ct=result&resnum=4&ved=0CDIQ6AEwAw#v=onepage&q&f=false <del style="font-weight: bold; text-decoration: none;">aBernhard </del>Lippert: Cisplatin - Chemistry and Biochemistry of a Leading Anticancer Drug]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* [http://books.google.si/books?id=Yii3zZRSb7cC&printsec=frontcover&dq=cisplatin&source=bl&ots=1xvu2n7yBg&sig=1r6VJhdzrEr8BIDmWNwMvxvoDM0&hl=sl&ei=H1IFTemUBZHqOYGlwaYB&sa=X&oi=book_result&ct=result&resnum=4&ved=0CDIQ6AEwAw#v=onepage&q&f=false <ins style="font-weight: bold; text-decoration: none;">Bernhard </ins>Lippert: Cisplatin - Chemistry and Biochemistry of a Leading Anticancer Drug]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Zunanje povezave ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Zunanje povezave ==</div></td></tr>
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Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4879&oldid=prev
Natasa: /* Viri */
2010-12-12T22:56:45Z
<p><span dir="auto"><span class="autocomment">Viri</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:56, 12 December 2010</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function.htm Delovanje cisplatina]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function.htm Delovanje cisplatina]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [http://books.google.si/books?id=Yii3zZRSb7cC&printsec=frontcover&dq=cisplatin&source=bl&ots=1xvu2n7yBg&sig=1r6VJhdzrEr8BIDmWNwMvxvoDM0&hl=sl&ei=H1IFTemUBZHqOYGlwaYB&sa=X&oi=book_result&ct=result&resnum=4&ved=0CDIQ6AEwAw#v=onepage&q&f=false aBernhard Lippert: Cisplatin - Chemistry and Biochemistry of a Leading Anticancer Drug]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Zunanje povezave ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Zunanje povezave ==</div></td></tr>
</table>
Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4876&oldid=prev
Natasa at 22:50, 12 December 2010
2010-12-12T22:50:19Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:50, 12 December 2010</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin je bil prvič opisan leta 1845. Njegova struktura je bila natančno opisana leta 1893. Raziskave na cisplatinu je izvajal Rosenberg leta 1865. Prvič je bil cisplatin uporabljen za zdravljenje raka leta 1978.<sup>[[Cisplatin#Viri|[2]]]</sup></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin je bil prvič opisan leta 1845. Njegova struktura je bila natančno opisana leta 1893. Raziskave na cisplatinu je izvajal Rosenberg leta 1865. Prvič je bil cisplatin uporabljen za zdravljenje raka leta 1978.<sup>[[Cisplatin#Viri|[2]]]</sup></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt. [http://www.cisplatin.org/images/cisplatin.png (Skica molekule)]. Njena <del style="font-weight: bold; text-decoration: none;">molska </del>masa je 300,05 g/mol.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt. [http://www.cisplatin.org/images/cisplatin.png (Skica molekule)]. Njena <ins style="font-weight: bold; text-decoration: none;">mol. </ins>masa je 300,05 g/mol.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s cisplatinom]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s cisplatinom]</div></td></tr>
</table>
Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4875&oldid=prev
Natasa: /* Viri */
2010-12-12T22:49:04Z
<p><span dir="auto"><span class="autocomment">Viri</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:49, 12 December 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l11">Line 11:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt. [http://www.cisplatin.org/images/cisplatin.png (Skica molekule)]. Njena molska masa je 300,05 g/mol.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt. [http://www.cisplatin.org/images/cisplatin.png (Skica molekule)]. Njena molska masa je 300,05 g/mol.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s <del style="font-weight: bold; text-decoration: none;">Cisplatinom</del>]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s <ins style="font-weight: bold; text-decoration: none;">cisplatinom</ins>]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function.htm Delovanje cisplatina]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function.htm Delovanje cisplatina]</div></td></tr>
</table>
Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4874&oldid=prev
Natasa at 22:47, 12 December 2010
2010-12-12T22:47:48Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:47, 12 December 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin spada v skupino alkilirajočih citostatičnih učinkovin. Poleg njega sta v tej skupini tudi karboplatin in oksaliplatin. Cisplatin uporabljamo pri zdravljenju različnih tipov raka, kot so sarkomi, pljučni rak, rak jajčnikov, limfni in tumorjev zarodnih celic. Aplicirajo ga kot intravenske infuzije za zdravljenje malignih obolenj. Cisplatin se je uporablja za kombinirano terapijo. Uporablja se ga tudi kot preventivno zdravljenje. <sup>[[Cisplatin#Viri|[1]]]</sup></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin spada v skupino alkilirajočih citostatičnih učinkovin. Poleg njega sta v tej skupini tudi karboplatin in oksaliplatin. Cisplatin uporabljamo pri zdravljenju različnih tipov raka, kot so sarkomi, pljučni rak, rak jajčnikov, limfni in tumorjev zarodnih celic. Aplicirajo ga kot intravenske infuzije za zdravljenje malignih obolenj. Cisplatin se je uporablja za kombinirano terapijo. Uporablja se ga tudi kot preventivno zdravljenje. <sup>[[Cisplatin#Viri|[1]]]</sup></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Molekula deluje in vivo, tako da zamreži molekule DNA in na ta način preprečuje delitev celic. V vodnem okolju telesa se kloridni atom v cisplatinu lahko zamenja s hidroksilno skupino <br /> ((PtCl)(H<sub>2</sub>O)(NH<sub>3</sub>)<sup>2+</sup>)in kasneje z delom DNA. Vodni ligant v tej molekuli se z lahkoto poveže na bazo v DNA, predvsem z gvaninom. Nastane ((PtCl(gvanin-DNA)NH<sub>3</sub>)<sup>2+</sup>). Platina povzroči premreženje dveh baz, pri tem se odstrani še drugi kloridni ligand. Poškodbi DNA sledi celična smrt (apoptoza).<del style="font-weight: bold; text-decoration: none;"><sup></del>[<del style="font-weight: bold; text-decoration: none;">[Cisplatin#Viri|[3]]</del>]<del style="font-weight: bold; text-decoration: none;"></sup></del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Molekula deluje in vivo, tako da zamreži molekule DNA in na ta način preprečuje delitev celic. V vodnem okolju telesa se kloridni atom v cisplatinu lahko zamenja s hidroksilno skupino <br /> ((PtCl)(H<sub>2</sub>O)(NH<sub>3</sub>)<sup>2+</sup>)in kasneje z delom DNA. Vodni ligant v tej molekuli se z lahkoto poveže na bazo v DNA, predvsem z gvaninom. Nastane ((PtCl(gvanin-DNA)NH<sub>3</sub>)<sup>2+</sup>). Platina povzroči premreženje dveh baz, pri tem se odstrani še drugi kloridni ligand. Poškodbi DNA sledi celična smrt (apoptoza). [<ins style="font-weight: bold; text-decoration: none;">http://www.youtube.com/watch?v=QfXc9gIt_hM (Video delovanja cisplatina)</ins>]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Pri visoki koncentraciji klorida v krvi reakcija zamenjave ne poteče hitro. Če pa je koncentracija kloridov v krvi nizka, cisplatin reagira z drugimi proteini. To pa ni učinkovito pri uničevanju rakavih celic.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Pri visoki koncentraciji klorida v krvi reakcija zamenjave ne poteče hitro. Če pa je koncentracija kloridov v krvi nizka, cisplatin reagira z drugimi proteini. To pa ni učinkovito pri uničevanju rakavih celic.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin povezuje DNA na različne načine in deluje pri celični delitvi mitozi. Poškodovan DNA vzpodbudi »popravni« DNA mehanizem. Vendar je obnova DNA nemogoča. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin povezuje DNA na različne načine in deluje pri celični delitvi mitozi. Poškodovan DNA vzpodbudi »popravni« DNA mehanizem. Vendar je obnova DNA nemogoča. </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Ugotovitev na rakavih celicah debelega črevesja: Apoptoza, ki je inducirana s strani cisplatina je odvisna od mitohondrijske serin-proteaze. Sprašujejo se, ali je ta mitohondrijska serin-proteaza prav tako učinkovita na drugih tkivih.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Ugotovitev na rakavih celicah debelega črevesja: Apoptoza, ki je inducirana s strani cisplatina je odvisna od mitohondrijske serin-proteaze. Sprašujejo se, ali je ta mitohondrijska serin-proteaza prav tako učinkovita na drugih tkivih. <ins style="font-weight: bold; text-decoration: none;"><sup>[[Cisplatin#Viri|[3]]]</sup></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin je bil prvič opisan leta 1845. Njegova struktura je bila natančno opisana leta 1893. Raziskave na cisplatinu je izvajal Rosenberg leta 1865. Prvič je bil cisplatin uporabljen za zdravljenje raka leta 1978.<sup>[[Cisplatin#Viri|[2]]]</sup></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin je bil prvič opisan leta 1845. Njegova struktura je bila natančno opisana leta 1893. Raziskave na cisplatinu je izvajal Rosenberg leta 1865. Prvič je bil cisplatin uporabljen za zdravljenje raka leta 1978.<sup>[[Cisplatin#Viri|[2]]]</sup></div></td></tr>
</table>
Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4870&oldid=prev
Natasa at 22:42, 12 December 2010
2010-12-12T22:42:57Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:42, 12 December 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin spada v skupino alkilirajočih citostatičnih učinkovin. Poleg njega sta v tej skupini tudi karboplatin in oksaliplatin. Cisplatin uporabljamo pri zdravljenju različnih tipov raka, kot so sarkomi, pljučni rak, rak jajčnikov, limfni in tumorjev zarodnih celic. Aplicirajo ga kot intravenske infuzije za zdravljenje malignih obolenj. Cisplatin se je uporablja za kombinirano terapijo. Uporablja se ga tudi kot preventivno zdravljenje. <sup>[[Cisplatin#Viri|[1]]]</sup></div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cisplatin spada v skupino alkilirajočih citostatičnih učinkovin. Poleg njega sta v tej skupini tudi karboplatin in oksaliplatin. Cisplatin uporabljamo pri zdravljenju različnih tipov raka, kot so sarkomi, pljučni rak, rak jajčnikov, limfni in tumorjev zarodnih celic. Aplicirajo ga kot intravenske infuzije za zdravljenje malignih obolenj. Cisplatin se je uporablja za kombinirano terapijo. Uporablja se ga tudi kot preventivno zdravljenje. <sup>[[Cisplatin#Viri|[1]]]</sup></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Molekula deluje in vivo, tako da zamreži molekule DNA in na ta način preprečuje delitev celic. V vodnem okolju telesa se kloridni atom v cisplatinu lahko zamenja s hidroksilno skupino <br /> ((PtCl)(H<sub>2</sub>O)(NH<sub>3</sub>)<sup>2+</sup>)in kasneje z delom DNA. Vodni ligant v tej molekuli se z lahkoto poveže na bazo v DNA, predvsem z gvaninom. Nastane ((PtCl(gvanin-DNA)NH<sub>3</sub>)<sup>2+</sup>). Platina povzroči premreženje dveh baz, pri tem se odstrani še drugi kloridni ligand. Poškodbi DNA sledi celična smrt (apoptoza).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Molekula deluje in vivo, tako da zamreži molekule DNA in na ta način preprečuje delitev celic. V vodnem okolju telesa se kloridni atom v cisplatinu lahko zamenja s hidroksilno skupino <br /> ((PtCl)(H<sub>2</sub>O)(NH<sub>3</sub>)<sup>2+</sup>)in kasneje z delom DNA. Vodni ligant v tej molekuli se z lahkoto poveže na bazo v DNA, predvsem z gvaninom. Nastane ((PtCl(gvanin-DNA)NH<sub>3</sub>)<sup>2+</sup>). Platina povzroči premreženje dveh baz, pri tem se odstrani še drugi kloridni ligand. Poškodbi DNA sledi celična smrt (apoptoza).<ins style="font-weight: bold; text-decoration: none;"><sup>[[Cisplatin#Viri|[3]]]</sup></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Pri visoki koncentraciji klorida v krvi reakcija zamenjave ne poteče hitro. Če pa je koncentracija kloridov v krvi nizka, cisplatin reagira z drugimi proteini. To pa ni učinkovito pri uničevanju rakavih celic.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Pri visoki koncentraciji klorida v krvi reakcija zamenjave ne poteče hitro. Če pa je koncentracija kloridov v krvi nizka, cisplatin reagira z drugimi proteini. To pa ni učinkovito pri uničevanju rakavih celic.</div></td></tr>
</table>
Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4868&oldid=prev
Natasa: /* Viri */
2010-12-12T22:41:48Z
<p><span dir="auto"><span class="autocomment">Viri</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-marker" />
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<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:41, 12 December 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l13">Line 13:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s Cisplatinom]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s Cisplatinom]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function Delovanje cisplatina]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[3]</sup> [http://www.cisplatin.org/function<ins style="font-weight: bold; text-decoration: none;">.htm </ins>Delovanje cisplatina]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
</table>
Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4867&oldid=prev
Natasa: /* Viri */
2010-12-12T22:41:23Z
<p><span dir="auto"><span class="autocomment">Viri</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:41, 12 December 2010</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l13">Line 13:</td>
<td colspan="2" class="diff-lineno">Line 13:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s Cisplatinom]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.cisplatin.org Informacije o zdravljenju s Cisplatinom]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* <sup>[3]</sup> [http://www.cisplatin.org/function Delovanje cisplatina]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
</table>
Natasa
https://wiki.fkkt.uni-lj.si/index.php?title=Cisplatin&diff=4866&oldid=prev
Natasa: /* Viri */
2010-12-12T22:39:20Z
<p><span dir="auto"><span class="autocomment">Viri</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:39, 12 December 2010</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt. [http://www.cisplatin.org/images/cisplatin.png (Skica molekule)]. Njena molska masa je 300,05 g/mol.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula cisplatina je H<sub>6</sub>Cl<sub>2</sub>N<sub>2</sub>Pt. [http://www.cisplatin.org/images/cisplatin.png (Skica molekule)]. Njena molska masa je 300,05 g/mol.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.<del style="font-weight: bold; text-decoration: none;">cistplatin</del>.org Informacije o zdravljenju s Cisplatinom]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[1]</sup> [http://www.<ins style="font-weight: bold; text-decoration: none;">cisplatin</ins>.org Informacije o zdravljenju s Cisplatinom]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* <sup>[2]</sup> [http://books.google.com/books?id=Cb6BOkj9fK4C&lpg=PA112&dq=taxol&pg=PA112#v=onepage&q=cisplatin&f=false W. Sneader: Drug discovery: a history, stran 64]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td></tr>
</table>
Natasa