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Fosfolipaza a - Revision history
2024-03-28T18:41:59Z
Revision history for this page on the wiki
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https://wiki.fkkt.uni-lj.si/index.php?title=Fosfolipaza_a&diff=7831&oldid=prev
MDolinar at 15:05, 1 February 2013
2013-02-01T15:05:54Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>- Od kalcija neodvisne fosfolipaze A2 (iPLA2):</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>- <ins style="font-weight: bold; text-decoration: none;">''</ins>Od kalcija neodvisne fosfolipaze A2 (iPLA2):<ins style="font-weight: bold; text-decoration: none;">''</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Hkrati so tudi transacilaze. Poznanih je 7 encimov. Imajo pomembno vlogo pri preurejanju membranskih fosfolipidov.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Hkrati so tudi transacilaze. Poznanih je 7 encimov. Imajo pomembno vlogo pri preurejanju membranskih fosfolipidov.</div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>- http://www.ffa.uni-lj.si/fileadmin/datoteke/Knjiznica/diplome/2009/Rezar_Cvetka_dipl_nal_2009.pdf</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* B. Jerman in J. Pungerčar: Sekretorne fosfolipaze A2 in njihova (pato)fiziološka vloga. Farm. Vestnik 2008: 59, 9</ins>-<ins style="font-weight: bold; text-decoration: none;">15 (!)</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>http://www.ffa.uni-lj.si/fileadmin/datoteke/Knjiznica/diplome/2009/Rezar_Cvetka_dipl_nal_2009.pdf</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">- </del>http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/index.html</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/index.html</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Fosfolipaza_a&diff=7830&oldid=prev
MDolinar at 14:55, 1 February 2013
2013-02-01T14:55:39Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 14:55, 1 February 2013</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''FOSFOLIPAZA A''' ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''FOSFOLIPAZA A''' ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Fosfolipaza </del>A <del style="font-weight: bold; text-decoration: none;">spade </del>med pankreatične encime in <del style="font-weight: bold; text-decoration: none;">siceR </del>v skupino [[<del style="font-weight: bold; text-decoration: none;">lipoliz</del>]]. Poznamo še fosfolipaze skupin B, C, D ter njihove podtipe. Fosfolipaze <del style="font-weight: bold; text-decoration: none;">A₂ </del>(<del style="font-weight: bold; text-decoration: none;">PLA₂</del>) so encimi različnih tipov, ki spadajo v večjo skupino fosfolipaz A. <del style="font-weight: bold; text-decoration: none;">PLA₂ </del>najdemo v vseh tkivih človeškega organizma, vključno s [http://sl.wikipedia.org/wiki/Krvna_plazma krvno plazmo]. Fosfolipaze <del style="font-weight: bold; text-decoration: none;">A₂ </del>so encimi, ki katalizirajo [[<del style="font-weight: bold; text-decoration: none;">cepitev </del>estrske vezi]] na mestu sn-2 v glicerofosfolipidih, pri čemer se sprostijo proste maščobne kisline in lizofosfolipidi. Pri sesalcih je bilo doslej odkritih 29 encimov <del style="font-weight: bold; text-decoration: none;">PLA₂</del>. Njihovo delovanje je znotraj- in zunajcelično. Večino slednjih predstavljajo sekretorne fosfolipaze <del style="font-weight: bold; text-decoration: none;">A₂</del>, ki so kot encimi ali pa ligandi za različne receptorje vpletene v številne fiziološke in patološke procese ([http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/naloga_fosfolipaza_A_3.gif slika produkta hidrolize membranskih fosfolipidov s fosfolipazo <del style="font-weight: bold; text-decoration: none;">A₂</del>]). To je spodbudilo farmacevtska podjetja k intenzivnemu razvoju specifičnih inhibitorjev za lajšanje, preprečevanje in zdravljenje obolenj, povezanih s sekretornimi fosfolipazami <del style="font-weight: bold; text-decoration: none;">A₂, </del>pri živalih in človeku. Fosfolipazo <del style="font-weight: bold; text-decoration: none;">A₂ </del>vsebujejo strupi nekaterih kač (kobra) in čebel. Razdeljeni so v 5 različnih skupin: </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Fosfolipaze </ins>A <ins style="font-weight: bold; text-decoration: none;">spadajo </ins>med pankreatične encime in <ins style="font-weight: bold; text-decoration: none;">sicer </ins>v skupino [[<ins style="font-weight: bold; text-decoration: none;">lipaze|lipaz</ins>]]. Poznamo še fosfolipaze skupin B, C, D ter njihove podtipe. Fosfolipaze <ins style="font-weight: bold; text-decoration: none;">A<sub>2</sub> </ins>(<ins style="font-weight: bold; text-decoration: none;">PLA2</ins>) so encimi različnih tipov, ki spadajo v večjo skupino fosfolipaz A. <ins style="font-weight: bold; text-decoration: none;">PLA2 </ins>najdemo v vseh tkivih človeškega organizma, vključno s [http://sl.wikipedia.org/wiki/Krvna_plazma krvno plazmo]. Fosfolipaze <ins style="font-weight: bold; text-decoration: none;">A2 </ins>so encimi, ki katalizirajo <ins style="font-weight: bold; text-decoration: none;">cepitev </ins>[[<ins style="font-weight: bold; text-decoration: none;">estrska vez|</ins>estrske vezi]] na mestu sn-2 v glicerofosfolipidih, pri čemer se sprostijo proste maščobne kisline in lizofosfolipidi. Pri sesalcih je bilo doslej odkritih 29 encimov <ins style="font-weight: bold; text-decoration: none;">PLA2</ins>. Njihovo delovanje je znotraj- in zunajcelično. Večino slednjih predstavljajo sekretorne fosfolipaze <ins style="font-weight: bold; text-decoration: none;">A2</ins>, ki so kot encimi ali pa ligandi za različne receptorje vpletene v številne fiziološke in patološke procese ([http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/naloga_fosfolipaza_A_3.gif slika produkta hidrolize membranskih fosfolipidov s fosfolipazo <ins style="font-weight: bold; text-decoration: none;">A2</ins>]). To je spodbudilo farmacevtska podjetja k intenzivnemu razvoju specifičnih inhibitorjev za lajšanje, preprečevanje in zdravljenje obolenj, povezanih s sekretornimi fosfolipazami <ins style="font-weight: bold; text-decoration: none;">A2 </ins>pri živalih in človeku. Fosfolipazo <ins style="font-weight: bold; text-decoration: none;">A2 </ins>vsebujejo strupi nekaterih kač (<ins style="font-weight: bold; text-decoration: none;">npr. </ins>kobra<ins style="font-weight: bold; text-decoration: none;">, modras</ins>) in čebel. Razdeljeni so v 5 različnih skupin: </div></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>- ''Sekretorne fosfolipaze <del style="font-weight: bold; text-decoration: none;">A₂ </del>(<del style="font-weight: bold; text-decoration: none;">sPLA₂</del>):''</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>- ''Sekretorne fosfolipaze <ins style="font-weight: bold; text-decoration: none;">A2 </ins>(<ins style="font-weight: bold; text-decoration: none;">sPLA2</ins>):''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">vključeni </del>so v različne (pato)fiziološke procese, kot so npr. metabolizem fosfolipidov, produkcija eikozanoidov, vnetje in primarni obrambni odziv gostitelja. Imajo majhne molekulske mase in potrebujejo <del style="font-weight: bold; text-decoration: none;">Ca²ᶧ </del>ion kot kofaktor. Obsega 11 encimov.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Vključene </ins>so v različne (pato)fiziološke procese, kot so npr. metabolizem fosfolipidov, produkcija eikozanoidov, vnetje in primarni obrambni odziv gostitelja. Imajo majhne molekulske mase in potrebujejo <ins style="font-weight: bold; text-decoration: none;">kalcijev (2+) </ins>ion kot kofaktor. Obsega 11 encimov.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>- ''Citosolne fosfolipaze <del style="font-weight: bold; text-decoration: none;">A₂ </del>(<del style="font-weight: bold; text-decoration: none;">cPLA₂</del>):''</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>- ''Citosolne fosfolipaze <ins style="font-weight: bold; text-decoration: none;">A2 </ins>(<ins style="font-weight: bold; text-decoration: none;">cPLA2</ins>):''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">obsega </del>6 encimov, med katerimi je najbolje raziskana vloga encima <del style="font-weight: bold; text-decoration: none;">cPLA₂ </del>, ki je ključen pri sproščanju arahidonske kisline (AA). Aktivacija <del style="font-weight: bold; text-decoration: none;">cPLA₂ </del>je tesno povezana s prisotnostjo <del style="font-weight: bold; text-decoration: none;">Ca²ᶧ </del>ionov in fosforilacijo.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Obsegajo </ins>6 encimov, med katerimi je najbolje raziskana vloga encima <ins style="font-weight: bold; text-decoration: none;">cPLA2</ins>, ki je ključen pri sproščanju <ins style="font-weight: bold; text-decoration: none;">[[arahidonska kislina|</ins>arahidonske kisline<ins style="font-weight: bold; text-decoration: none;">]] </ins>(AA). Aktivacija <ins style="font-weight: bold; text-decoration: none;">cPLA2 </ins>je tesno povezana s prisotnostjo <ins style="font-weight: bold; text-decoration: none;">Ca-</ins>ionov in fosforilacijo.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">- Od kalcija neodvisne fosfolipaze A2 (iPLA2):</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">- Ca²ᶧ -neodvisne fosfolipaze A₂ (iPLA₂):</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Hkrati so tudi transacilaze. Poznanih je 7 encimov. Imajo pomembno vlogo pri preurejanju membranskih fosfolipidov.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">hkrati so tudi transacilaze. Poznanih je 7 encimov. Imajo pomembno vlogo pri preurejanju membranskih fosfolipidov.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">- ''PAF–acetilhidrolaze (PAF-AH):''</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>- <del style="font-weight: bold; text-decoration: none;">''</del>PAF <del style="font-weight: bold; text-decoration: none;">– acetilhidrolaz (</del>PAF-AH<del style="font-weight: bold; text-decoration: none;">):''</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Znani so 4 encimi, katerih edinstveni lastnosti sta substratna specifičnost za [[trombocitni aktivator]] in oksidirane fosfolipide, ki imajo oksidirane maščobne kisline dolžine do 9 ogljikovih atomov. PAF</ins>-<ins style="font-weight: bold; text-decoration: none;">AH za razliko od ostalih PLA2 ne delujejo učinkovito na površini lipidnih membran, temveč bolje hidrolizirajo monomerne substrate v raztopini. Cepitev </ins>PAF <ins style="font-weight: bold; text-decoration: none;">in oksidiranih fosfolipidov s </ins>PAF-AH <ins style="font-weight: bold; text-decoration: none;">lahko vodi do zaključka vnetja ali ateroskleroze.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">poznani so 4 encimi, katerih edinstveni lastnosti sta substratna specifičnost za</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">trombocitni aktivator in oksidirane fosfolipide, ki imajo oksidirane maščobne kisline dolžine do 9 ogljikovih atomov. PAF-AH za razliko od ostalih PLA₂ ne delujejo učinkovito na površini lipidnih membran, temveč bolje hidrolizirajo monomerne substrate v </del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">raztopini. Cepitev PAF in oksidiranih fosfolipidov s PAF-AH lahko vodi do zaključka vnetja ali ateroskleroze.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">- ''Lizosomske fosfolipaze A2:''</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">- ''Lizosomske fosfolipaze A₂:''</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Zaenkrat je sem </ins>uvrščena le ena fosfolipaza, ki ima od <ins style="font-weight: bold; text-decoration: none;">Ca</ins>-neodvisno fosfolipazno aktivnost in transacilazno aktivnost, podobno kot <ins style="font-weight: bold; text-decoration: none;">iPLA2</ins>.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">zaenkrat </del>uvrščena le ena fosfolipaza, ki ima od <del style="font-weight: bold; text-decoration: none;">Ca²ᶧ</del>-neodvisno fosfolipazno aktivnost in transacilazno aktivnost, podobno kot <del style="font-weight: bold; text-decoration: none;">iPLA₂</del>.</div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>- http://www.ffa.uni-lj.si/fileadmin/datoteke/Knjiznica/diplome/2009/Rezar_Cvetka_dipl_nal_2009.pdf</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>- http://www.ffa.uni-lj.si/fileadmin/datoteke/Knjiznica/diplome/2009/Rezar_Cvetka_dipl_nal_2009.pdf</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">- http://www.medenosrce.net/tiskaj.asp?id=74</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>- http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/index.html</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>- http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/index.html</div></td></tr>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Fosfolipaza_a&diff=4956&oldid=prev
Belkisa at 10:32, 13 December 2010
2010-12-13T10:32:15Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:32, 13 December 2010</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>- http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>- http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/</div></td></tr>
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Belkisa
https://wiki.fkkt.uni-lj.si/index.php?title=Fosfolipaza_a&diff=4946&oldid=prev
Belkisa: New page: == '''FOSFOLIPAZA A''' == Fosfolipaza A spade med pankreatične encime in siceR v skupino lipoliz. Poznamo še fosfolipaze skupin B, C, D ter njihove podtipe. Fosfolipaze A₂ (PLA...
2010-12-13T10:17:56Z
<p>New page: == '''FOSFOLIPAZA A''' == Fosfolipaza A spade med pankreatične encime in siceR v skupino <a href="/index.php?title=Lipoliz&action=edit&redlink=1" class="new" title="Lipoliz (page does not exist)">lipoliz</a>. Poznamo še fosfolipaze skupin B, C, D ter njihove podtipe. Fosfolipaze A₂ (PLA...</p>
<p><b>New page</b></p><div>== '''FOSFOLIPAZA A''' ==<br />
<br />
Fosfolipaza A spade med pankreatične encime in siceR v skupino [[lipoliz]]. Poznamo še fosfolipaze skupin B, C, D ter njihove podtipe. Fosfolipaze A₂ (PLA₂) so encimi različnih tipov, ki spadajo v večjo skupino fosfolipaz A. PLA₂ najdemo v vseh tkivih človeškega organizma, vključno s [http://sl.wikipedia.org/wiki/Krvna_plazma krvno plazmo]. Fosfolipaze A₂ so encimi, ki katalizirajo [[cepitev estrske vezi]] na mestu sn-2 v glicerofosfolipidih, pri čemer se sprostijo proste maščobne kisline in lizofosfolipidi. Pri sesalcih je bilo doslej odkritih 29 encimov PLA₂. Njihovo delovanje je znotraj- in zunajcelično. Večino slednjih predstavljajo sekretorne fosfolipaze A₂, ki so kot encimi ali pa ligandi za različne receptorje vpletene v številne fiziološke in patološke procese ([http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/naloga_fosfolipaza_A_3.gif slika produkta hidrolize membranskih fosfolipidov s fosfolipazo A₂]). To je spodbudilo farmacevtska podjetja k intenzivnemu razvoju specifičnih inhibitorjev za lajšanje, preprečevanje in zdravljenje obolenj, povezanih s sekretornimi fosfolipazami A₂, pri živalih in človeku. Fosfolipazo A₂ vsebujejo strupi nekaterih kač (kobra) in čebel. Razdeljeni so v 5 različnih skupin: <br />
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- ''Sekretorne fosfolipaze A₂ (sPLA₂):''<br />
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vključeni so v različne (pato)fiziološke procese, kot so npr. metabolizem fosfolipidov, produkcija eikozanoidov, vnetje in primarni obrambni odziv gostitelja. Imajo majhne molekulske mase in potrebujejo Ca²ᶧ ion kot kofaktor. Obsega 11 encimov.<br />
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- ''Citosolne fosfolipaze A₂ (cPLA₂):''<br />
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obsega 6 encimov, med katerimi je najbolje raziskana vloga encima cPLA₂ , ki je ključen pri sproščanju arahidonske kisline (AA). Aktivacija cPLA₂ je tesno povezana s prisotnostjo Ca²ᶧ ionov in fosforilacijo.<br />
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- Ca²ᶧ -neodvisne fosfolipaze A₂ (iPLA₂):<br />
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hkrati so tudi transacilaze. Poznanih je 7 encimov. Imajo pomembno vlogo pri preurejanju membranskih fosfolipidov.<br />
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- ''PAF – acetilhidrolaz (PAF-AH):''<br />
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poznani so 4 encimi, katerih edinstveni lastnosti sta substratna specifičnost za<br />
trombocitni aktivator in oksidirane fosfolipide, ki imajo oksidirane maščobne kisline dolžine do 9 ogljikovih atomov. PAF-AH za razliko od ostalih PLA₂ ne delujejo učinkovito na površini lipidnih membran, temveč bolje hidrolizirajo monomerne substrate v <br />
raztopini. Cepitev PAF in oksidiranih fosfolipidov s PAF-AH lahko vodi do zaključka vnetja ali ateroskleroze.<br />
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- ''Lizosomske fosfolipaze A₂:''<br />
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zaenkrat uvrščena le ena fosfolipaza, ki ima od Ca²ᶧ-neodvisno fosfolipazno aktivnost in transacilazno aktivnost, podobno kot iPLA₂.<br />
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== '''Viri:''' ==<br />
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<br />
- http://www.ffa.uni-lj.si/fileadmin/datoteke/Knjiznica/diplome/2009/Rezar_Cvetka_dipl_nal_2009.pdf<br />
<br />
- http://www.medenosrce.net/tiskaj.asp?id=74<br />
<br />
- http://www.kii3.ntf.uni-lj.si/e-kemija/file.php/1/output/lipidi3/index.html<br />
<br />
- http://www.lek.si/si/skrb-za-zdravje/medicinski-slovar/</div>
Belkisa