Vloga koronavirusne endonukleaze pri izogibanju protivirusnemu odgovoru

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Uvod

UPR in možni mehanizem stresa na ER, ki ga povzroča koronavirus

p38 MAPK in Sars-CoV-2

JNK in Sars-CoV

Kako koronavirusi uravnavajo translacijo

Literatura

1. Deng X, Baker SC. An “Old” protein with a new story: Coronavirus endoribonuclease is important for evading host antiviral defenses. Virology. 2018;517: 157–163. doi:10.1016/j.virol.2017.12.024

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4. Deng X, Hackbart M, Mettelman RC, O’Brien A, Mielech AM, Yi G, et al. Coronavirus nonstructural protein 15 mediates evasion of dsRNA sensors and limits apoptosis in macrophages. Proc Natl Acad Sci USA. 2017;114: E4251–E4260. doi:10.1073/pnas.1618310114