https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Acetilholinesteraza 2026-04-14T08:40:23Z Revision history for this page on the wiki MediaWiki 1.39.3 https://wiki.fkkt.uni-lj.si/index.php?title=Acetilholinesteraza&diff=8735&oldid=prev 2014-01-07T19:52:37Z

<p><span dir="auto"><span class="autocomment">Zunanje povezave</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:52, 7 January 2014</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l33">Line 33:</td> <td colspan="2" class="diff-lineno">Line 33:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://www.rcsb.org/pdb/101/motm.do?momID=54 Acetylcholinesterase June 2004 Molecule of the Month]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://www.rcsb.org/pdb/101/motm.do?momID=54 Acetylcholinesterase June 2004 Molecule of the Month]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[ [Category:LEX] ]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td></tr> </table>

Pirman0 https://wiki.fkkt.uni-lj.si/index.php?title=Acetilholinesteraza&diff=8734&oldid=prev 2014-01-07T19:52:00Z

<p><span dir="auto"><span class="autocomment">Zunanje povezave</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:52, 7 January 2014</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l30">Line 30:</td> <td colspan="2" class="diff-lineno">Line 30:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://www.proteopedia.org/wiki/index.php/Acetylcholinesterase 3D structure of acetylcholinesterase]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://www.proteopedia.org/wiki/index.php/Acetylcholinesterase 3D structure of acetylcholinesterase]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://www.rcsb.org/pdb/101/motm.do?momID=54 Acetylcholinesterase June 2004 Molecule of the Month]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://www.rcsb.org/pdb/101/motm.do?momID=54 Acetylcholinesterase June 2004 Molecule of the Month]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[ [Category:LEX] ]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[ [Category:LEX] ]</div></td></tr> </table>

Pirman0 https://wiki.fkkt.uni-lj.si/index.php?title=Acetilholinesteraza&diff=8733&oldid=prev 2014-01-07T19:51:44Z

<p><span dir="auto"><span class="autocomment">Viri</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:51, 7 January 2014</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l16">Line 16:</td> <td colspan="2" class="diff-lineno">Line 16:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Boyer, Rodney F. Temelji Biokemije. Ljubljana, 2005.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Boyer, Rodney F. Temelji Biokemije. Ljubljana, 2005.</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Hill, Richard W., Wyse, Gordon A., Anderson, Margaret. Animal Psysiology. Sunderland (Massachusetts), 2012.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Hill, Richard W., Wyse, Gordon A., Anderson, Margaret. Animal Psysiology. Sunderland (Massachusetts), 2012.</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>MacDonald, Richard G., Chaney, William G. USMLE Road map: Biochemistry. New York, 2007.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>MacDonald, Richard G., Chaney, William G. USMLE Road map: Biochemistry. New York, 2007.</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Walker, Sharon, McMahon, David. Biochemistry Demystified. New York, 2008.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Walker, Sharon, McMahon, David. Biochemistry Demystified. New York, 2008.</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Whitaker, John R. Principles of Enzymology for the Food Sciences. New York, 1972.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Whitaker, John R. Principles of Enzymology for the Food Sciences. New York, 1972.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> </table>

Pirman0 https://wiki.fkkt.uni-lj.si/index.php?title=Acetilholinesteraza&diff=8732&oldid=prev 2014-01-07T19:51:22Z

<p>New page: Acetilholinesteraza ali acetilidrolaza, krajše tudi AChE, je encim, ki ga uvrščamo med hidrolaze,saj hidrolizira nevrotransmiter (živčni prenašalec) <a href="/index.php/Acetilholin" title="Acetilholin">acetilholin</a>. Acetilholinester...</p> <p><b>New page</b></p><div>Acetilholinesteraza ali acetilidrolaza, krajše tudi AChE, je encim, ki ga uvrščamo med hidrolaze,saj hidrolizira nevrotransmiter (živčni prenašalec) [[acetilholin]]. Acetilholinesteraza se nahaja predvsem na stikih med živci in mišico, kjer prekine prenos živčnih signalov med živcem in mišico.<br /> <br /> <br /> == Encimska struktura in mehanizem ==<br /> <br /> <br /> Acetilholinesteraza ima zelo visoko katalitično aktivnost, saj vsaka molekula tega encima razgradi 25000 molekul acetilholina v eni sekundi. To predstavlja tako hitrost razgradnje, kot je približna hitrost difuzije substrata, zato lahko encimu acetilholinesteraza rečemo tudi popolni encim.<br /> Aktivno mesto acetilholinesteraze obsega dve podmesti, anionsko mesto in estersko mesto. Na anionsko mesto se veže pozitivni kvartarni amin iz molekule acetilholina, lahko pa tudi kationski substrati in inhibitorji. Estersko mesto je sestavljeno iz katalitične triade treh aminokislin, in sicer serina, histidina in glutamata. Na tem mestu se acetilholin hidrolizira v acetat in holin, tako da nastane acetil-encim in prosti [[holin]]. Acetil-encim se kasneje razgradi na prost encim, ki je sposoben ponovnega delovanja, in acetilno skupino. To se zgodi ob prisotnosti vode in aminokisline [[histidin]].<br /> <br /> == Biološka funkcija ==<br /> <br /> Med prenosom živčnih signalov, [[acetilholin]] preide iz živca v sinaptično režo, kjer se veže na ACh receptorje na postsinaptični membrani in tako prenaša živčne signale. Acetilholinesteraza, ki se tudi nahaja na postsinaptični membrani, prekine prenos signalov, tako da hidrolizira [[acetilholin]]. Novonastali prosti holin se prenese nazaj v živec, kjer se iz acetil-koencima A preko delovanja acetilholintransferaza ponovno sintetizira c [[acetilholin]].<br /> <br /> <br /> == Viri ==<br /> <br /> Boyer, Rodney F. Temelji Biokemije. Ljubljana, 2005.<br /> Hill, Richard W., Wyse, Gordon A., Anderson, Margaret. Animal Psysiology. Sunderland (Massachusetts), 2012.<br /> MacDonald, Richard G., Chaney, William G. USMLE Road map: Biochemistry. New York, 2007.<br /> Walker, Sharon, McMahon, David. Biochemistry Demystified. New York, 2008.<br /> Whitaker, John R. Principles of Enzymology for the Food Sciences. New York, 1972.<br /> <br /> [http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase, Wikipedia]<br /> <br /> == Zunanje povezave ==<br /> <br /> [http://www.proteopedia.org/wiki/index.php/Acetylcholinesterase 3D structure of acetylcholinesterase]<br /> [http://www.rcsb.org/pdb/101/motm.do?momID=54 Acetylcholinesterase June 2004 Molecule of the Month]<br /> <br /> [ [Category:LEX] ]</div>

Pirman0