https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Fosfolipaze_%28splo%C5%A1no%29
Fosfolipaze (splošno) - Revision history
2026-07-02T23:55:12Z
Revision history for this page on the wiki
MediaWiki 1.45.3
https://wiki.fkkt.uni-lj.si/index.php?title=Fosfolipaze_(splo%C5%A1no)&diff=5343&oldid=prev
MDolinar at 11:20, 4 February 2011
2011-02-04T11:20:03Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:20, 4 February 2011</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Fosfolipaze''' so v naravi zelo razširjeni encimi, ki hidrolizirajo estrske vezi na fosfolipidih. Glede na položaj estrske vezi v fosfogliceridu, ki jo cepijo, jih delimo fosfolipaze '''A1''', '''A2''', '''B''', '''C''' in '''D'''. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Fosfolipaze''' so v naravi zelo razširjeni encimi, ki hidrolizirajo estrske vezi na fosfolipidih. Glede na položaj estrske vezi v fosfogliceridu, ki jo cepijo, jih delimo fosfolipaze '''A1''', '''A2''', '''B''', '''C''' in '''D'''. </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fosfolipaze naravnega izvora se uporabljajo za</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Fosfolipaze naravnega izvora se uporabljajo za<ins style="font-weight: bold; text-decoration: none;">:</ins></div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">1. </del>ugotavljanje strukturne funkcije fosfolipidov in njihove vlogo</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># </ins>ugotavljanje strukturne funkcije fosfolipidov in njihove vlogo</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">2. </del>določanje asimetrične organizacije fosfolipidov v bioloških membranah</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># </ins>določanje asimetrične organizacije fosfolipidov v bioloških membranah</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">3. </del>kot modeli intracelularnih sesalskih fosfolipaz, ki jih ne moremo dobiti v zadostnih količinah za encimatske ali farmakološke študije</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># </ins>kot modeli intracelularnih sesalskih fosfolipaz, ki jih ne moremo dobiti v zadostnih količinah za encimatske ali farmakološke študije</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">4. </del>kot pontencialni modeli kliničnih motenj.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"># </ins>kot pontencialni modeli kliničnih motenj.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>So komponente različnih kačjih strupov, toksinov in različnih strupenih snovi. Če </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>So komponente različnih kačjih strupov, toksinov in različnih strupenih snovi. Če </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>želimo razumeti njihovo delovanje, moramo poznati tudi delovanje posameznih sestavin v čisti obliki.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>želimo razumeti njihovo delovanje, moramo poznati tudi delovanje posameznih sestavin v čisti obliki.</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l11">Line 11:</td>
<td colspan="2" class="diff-lineno">Line 11:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[fosfolipazo C]] (PLC) producira vrsta bakterij, med katerimi je najpomembnejša bakterija vrste Clostridium perfringens, ki sprošča fosfolipazo C z letalnim učinkom pod imenom α-toksin. α-toksin je bil prvi bakterijski toksin okarakteriziran kot encim; je letalen, citolitičen in nekrotičen.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[fosfolipazo C]] (PLC) producira vrsta bakterij, med katerimi je najpomembnejša bakterija vrste Clostridium perfringens, ki sprošča fosfolipazo C z letalnim učinkom pod imenom α-toksin. α-toksin je bil prvi bakterijski toksin okarakteriziran kot encim; je letalen, citolitičen in nekrotičen.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Fosfolipazo D (PLD) so najprej našli v rastlinskih celicah in so rastline še vedno najpogostejši vir tega encima. Nahaja se tudi v bakterijah in sesalskih tkivih.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Fosfolipazo D (PLD) so najprej našli v rastlinskih celicah in so rastline še vedno najpogostejši vir tega encima. Nahaja se tudi v bakterijah in sesalskih tkivih.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Slike:</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* http://www.phmd.pl/images/ryciny/20080111114847.jpg</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* http://www.phmd.pl/images/ryciny/20060308093740.jpg</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [http://www.google.si/imgres?imgurl=http://bioinfo.mol.uj.edu.pl/articles/Florkowska08/Abstract%3Faction%3DAttachFile%26do%3Dget%26target%3Denzymy.jpg&imgrefurl=http://bioinfo.mol.uj.edu.pl/articles/Florkowska08&usg=__sFUhTHclnWGaMDPw8tVIWbXby8w=&h=223&w=423&sz=11&hl=sl&start=19&zoom=1&tbnid=YG9du8Vzzm83yM:&tbnh=85&tbnw=161&prev=/images%3Fq%3Dfosfolipaza%26um%3D1%26hl%3Dsl%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:sl:official%26biw%3D1366%26bih%3D585%26tbs%3Disch:10%2C570&um=1&itbs=1&iact=rc&dur=504&ei=vDcCTfbZBcbzsgbjy5T-CQ&oei=jDcCTa6cJ9Dxsgaho4j1CQ&esq=2&page=2&ndsp=21&ved=1t:429,r:14,s:19&tx=75&ty=61&biw=1366&bih=585 Mesta delovanja različnih fosfolipaz]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l16">Line 16:</td>
<td colspan="2" class="diff-lineno">Line 22:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* J. Šribar: Izolacija dveh visokomolekularnih receptorjev fosfolipaz A2 iz prašiča in njuna nadaljna karakterizacija, stran 1 in 2 </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* J. Šribar: Izolacija dveh visokomolekularnih receptorjev fosfolipaz A2 iz prašiča in njuna nadaljna karakterizacija, stran 1 in 2 </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Zunanje povezave ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://www.google.si/imgres?imgurl=http://www.phmd.pl/images/ryciny/20080111114847.jpg&imgrefurl=http://www.phmd.pl/fulltxthtml.php%3FICID%3D675651&usg=__xE7h0ci2wREKuIZf1XmBiIt94RQ=&h=376&w=568&sz=24&hl=sl&start=0&zoom=1&tbnid=23cu1G7sBiCcbM:&tbnh=133&tbnw=201&prev=/images%3Fq%3Dfosfolipaza%26um%3D1%26hl%3Dsl%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:sl:official%26biw%3D1366%26bih%3D585%26tbs%3Disch:1&um=1&itbs=1&iact=hc&vpx=344&vpy=247&dur=282&hovh=165&hovw=250&tx=146&ty=87&ei=tTYCTc7WLcmztAbQjtDsCQ&oei=tTYCTc7WLcmztAbQjtDsCQ&esq=1&page=1&ndsp=19&ved=1t:429,r:7,s:0 Postepy i higieny i medycyny dojwiadczalnej]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://www.google.si/imgres?imgurl=http://www.phmd.pl/images/ryciny/20060308093740.jpg&imgrefurl=http://www.phmd.pl/fulltxthtml.php%3FICID%3D446414&usg=__UgVu0Vr4rC0B3MiB3EgzIpamOd4=&h=286&w=423&sz=11&hl=sl&start=0&zoom=1&tbnid=AdlEm_kjk2wuDM:&tbnh=139&tbnw=198&prev=/images%3Fq%3Dfosfolipaza%26um%3D1%26hl%3Dsl%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:sl:official%26biw%3D1366%26bih%3D585%26tbs%3Disch:1&um=1&itbs=1&iact=rc&dur=379&ei=jDcCTa6cJ9Dxsgaho4j1CQ&oei=jDcCTa6cJ9Dxsgaho4j1CQ&esq=1&page=1&ndsp=19&ved=1t:429,r:4,s:0&tx=137&ty=81 Postepy i higieny i medycyny dojwiadczalnej]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://www.google.si/imgres?imgurl=http://bioinfo.mol.uj.edu.pl/articles/Florkowska08/Abstract%3Faction%3DAttachFile%26do%3Dget%26target%3Denzymy.jpg&imgrefurl=http://bioinfo.mol.uj.edu.pl/articles/Florkowska08&usg=__sFUhTHclnWGaMDPw8tVIWbXby8w=&h=223&w=423&sz=11&hl=sl&start=19&zoom=1&tbnid=YG9du8Vzzm83yM:&tbnh=85&tbnw=161&prev=/images%3Fq%3Dfosfolipaza%26um%3D1%26hl%3Dsl%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:sl:official%26biw%3D1366%26bih%3D585%26tbs%3Disch:10%2C570&um=1&itbs=1&iact=rc&dur=504&ei=vDcCTfbZBcbzsgbjy5T-CQ&oei=jDcCTa6cJ9Dxsgaho4j1CQ&esq=2&page=2&ndsp=21&ved=1t:429,r:14,s:19&tx=75&ty=61&biw=1366&bih=585 Articles wiki]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td></tr>
</table>
MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Fosfolipaze_(splo%C5%A1no)&diff=5341&oldid=prev
MDolinar: User talk:New.year moved to Fosfolipaze (splošno): objavljeno kot User talk
2011-02-04T11:12:56Z
<p><a href="/index.php?title=User_talk:New.year&action=edit&redlink=1" class="new" title="User talk:New.year (page does not exist)">User talk:New.year</a> moved to <a href="/index.php?title=Fosfolipaze_(splo%C5%A1no)" title="Fosfolipaze (splošno)">Fosfolipaze (splošno)</a>: objavljeno kot User talk</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<tr class="diff-title" lang="en">
<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:12, 4 February 2011</td>
</tr><tr><td colspan="2" class="diff-notice" lang="en"><div class="mw-diff-empty">(No difference)</div>
</td></tr></table>
MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Fosfolipaze_(splo%C5%A1no)&diff=4428&oldid=prev
New.year: New page: '''Fosfolipaze''' so v naravi zelo razširjeni encimi, ki hidrolizirajo estrske vezi na fosfolipidih. Glede na položaj estrske vezi v fosfogliceridu, ki jo cepijo, jih delimo fosfolipaze...
2010-12-10T14:47:20Z
<p>New page: '''Fosfolipaze''' so v naravi zelo razširjeni encimi, ki hidrolizirajo estrske vezi na fosfolipidih. Glede na položaj estrske vezi v fosfogliceridu, ki jo cepijo, jih delimo fosfolipaze...</p>
<p><b>New page</b></p><div>'''Fosfolipaze''' so v naravi zelo razširjeni encimi, ki hidrolizirajo estrske vezi na fosfolipidih. Glede na položaj estrske vezi v fosfogliceridu, ki jo cepijo, jih delimo fosfolipaze '''A1''', '''A2''', '''B''', '''C''' in '''D'''. <br />
Fosfolipaze naravnega izvora se uporabljajo za<br />
1. ugotavljanje strukturne funkcije fosfolipidov in njihove vlogo<br />
2. določanje asimetrične organizacije fosfolipidov v bioloških membranah<br />
3. kot modeli intracelularnih sesalskih fosfolipaz, ki jih ne moremo dobiti v zadostnih količinah za encimatske ali farmakološke študije<br />
4. kot pontencialni modeli kliničnih motenj.<br />
So komponente različnih kačjih strupov, toksinov in različnih strupenih snovi. Če <br />
želimo razumeti njihovo delovanje, moramo poznati tudi delovanje posameznih sestavin v čisti obliki.<br />
Fosfolipaza A1 (PLA1) je tako v evkariontskih kot prokariontskih celicah, je topen encim, ki je lizosomih in citoplazmi, ima kisel pH optimum, medtem ko pa je pH-optimuma encima vezanega na membrano bazičen.<br />
Fosfolipaza A2 /PLA2) je zelo pomembna pri astmi, saj s svojim delovanjem sprošča arahidonsko kislino, ki je prekurzor za prostaglandine, leukotriene in tromboksane.<br />
[[fosfolipazo C]] (PLC) producira vrsta bakterij, med katerimi je najpomembnejša bakterija vrste Clostridium perfringens, ki sprošča fosfolipazo C z letalnim učinkom pod imenom α-toksin. α-toksin je bil prvi bakterijski toksin okarakteriziran kot encim; je letalen, citolitičen in nekrotičen.<br />
Fosfolipazo D (PLD) so najprej našli v rastlinskih celicah in so rastline še vedno najpogostejši vir tega encima. Nahaja se tudi v bakterijah in sesalskih tkivih.<br />
<br />
== Viri ==<br />
* V. Čurin Šerbec: Študij toksičnega mesta na amododitoksinu A s pomočjo monoklinskih teles, stran 4,5 in 6<br />
* J. Šribar: Izolacija dveh visokomolekularnih receptorjev fosfolipaz A2 iz prašiča in njuna nadaljna karakterizacija, stran 1 in 2 <br />
<br />
<br />
== Zunanje povezave ==<br />
[http://www.google.si/imgres?imgurl=http://www.phmd.pl/images/ryciny/20080111114847.jpg&imgrefurl=http://www.phmd.pl/fulltxthtml.php%3FICID%3D675651&usg=__xE7h0ci2wREKuIZf1XmBiIt94RQ=&h=376&w=568&sz=24&hl=sl&start=0&zoom=1&tbnid=23cu1G7sBiCcbM:&tbnh=133&tbnw=201&prev=/images%3Fq%3Dfosfolipaza%26um%3D1%26hl%3Dsl%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:sl:official%26biw%3D1366%26bih%3D585%26tbs%3Disch:1&um=1&itbs=1&iact=hc&vpx=344&vpy=247&dur=282&hovh=165&hovw=250&tx=146&ty=87&ei=tTYCTc7WLcmztAbQjtDsCQ&oei=tTYCTc7WLcmztAbQjtDsCQ&esq=1&page=1&ndsp=19&ved=1t:429,r:7,s:0 Postepy i higieny i medycyny dojwiadczalnej]<br />
<br />
[http://www.google.si/imgres?imgurl=http://www.phmd.pl/images/ryciny/20060308093740.jpg&imgrefurl=http://www.phmd.pl/fulltxthtml.php%3FICID%3D446414&usg=__UgVu0Vr4rC0B3MiB3EgzIpamOd4=&h=286&w=423&sz=11&hl=sl&start=0&zoom=1&tbnid=AdlEm_kjk2wuDM:&tbnh=139&tbnw=198&prev=/images%3Fq%3Dfosfolipaza%26um%3D1%26hl%3Dsl%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:sl:official%26biw%3D1366%26bih%3D585%26tbs%3Disch:1&um=1&itbs=1&iact=rc&dur=379&ei=jDcCTa6cJ9Dxsgaho4j1CQ&oei=jDcCTa6cJ9Dxsgaho4j1CQ&esq=1&page=1&ndsp=19&ved=1t:429,r:4,s:0&tx=137&ty=81 Postepy i higieny i medycyny dojwiadczalnej]<br />
<br />
[http://www.google.si/imgres?imgurl=http://bioinfo.mol.uj.edu.pl/articles/Florkowska08/Abstract%3Faction%3DAttachFile%26do%3Dget%26target%3Denzymy.jpg&imgrefurl=http://bioinfo.mol.uj.edu.pl/articles/Florkowska08&usg=__sFUhTHclnWGaMDPw8tVIWbXby8w=&h=223&w=423&sz=11&hl=sl&start=19&zoom=1&tbnid=YG9du8Vzzm83yM:&tbnh=85&tbnw=161&prev=/images%3Fq%3Dfosfolipaza%26um%3D1%26hl%3Dsl%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:sl:official%26biw%3D1366%26bih%3D585%26tbs%3Disch:10%2C570&um=1&itbs=1&iact=rc&dur=504&ei=vDcCTfbZBcbzsgbjy5T-CQ&oei=jDcCTa6cJ9Dxsgaho4j1CQ&esq=2&page=2&ndsp=21&ved=1t:429,r:14,s:19&tx=75&ty=61&biw=1366&bih=585 Articles wiki]<br />
<br />
[[Category:LEX]]</div>
New.year