https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Heksokinaza 2026-05-23T00:41:27Z Revision history for this page on the wiki MediaWiki 1.45.3 https://wiki.fkkt.uni-lj.si/index.php?title=Heksokinaza&diff=3065&oldid=prev 2010-02-19T11:08:01Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:08, 19 February 2010</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l2">Line 2:</td> <td colspan="2" class="diff-lineno">Line 2:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Heksokinaza je encim, ki <del style="font-weight: bold; text-decoration: none;">fosforilizira šest-ogljikov sladkor, </del>heksozo<del style="font-weight: bold; text-decoration: none;">, nastane hekso fosfat</del>. V večini tkiv in organizmov<del style="font-weight: bold; text-decoration: none;">, </del>je glukoza najpomembnejši substrat heksokinaze, in glukoza-6-fosfat najpomembnejši produkt.  </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Heksokinaza je encim, ki <ins style="font-weight: bold; text-decoration: none;">fosforilira [[heksoza|</ins>heksozo<ins style="font-weight: bold; text-decoration: none;">]] v heksozafosfat</ins>. V večini tkiv in organizmov je glukoza najpomembnejši substrat heksokinaze, in glukoza-6-fosfat najpomembnejši produkt.  </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Glukoza je edinstvena v tem, da se lahko uporablja kot vir energije, ki ga vse celice uporabljajo v navzočnosti ali ob odsotnosti molekularnega kisika (O2)<del style="font-weight: bold; text-decoration: none;">. Glukoza presnovo preko presnovne poti znana kot glikoliza, je pomembno povezano z mitohondrijskimi oksidativnimi presnovami v prisotnosti kisika, ampak lahko tudi glikoliza ustvarja ATP v odsotnosti</del>. Prvi korak v <del style="font-weight: bold; text-decoration: none;">tem </del>zaporedju reakcij je fosforilacija glukoze, heksokinaza <del style="font-weight: bold; text-decoration: none;">za pripravo </del>na <del style="font-weight: bold; text-decoration: none;">poznejše razdelitve</del>, <del style="font-weight: bold; text-decoration: none;">da se zagotovi </del>energijo.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Glukoza je edinstvena v tem, da se lahko uporablja kot vir energije, ki ga vse celice uporabljajo v navzočnosti ali ob odsotnosti molekularnega kisika (O2). Prvi korak v zaporedju reakcij <ins style="font-weight: bold; text-decoration: none;">razgradnje glukoze </ins>je fosforilacija glukoze, <ins style="font-weight: bold; text-decoration: none;">ki jo katalizira </ins>heksokinaza<ins style="font-weight: bold; text-decoration: none;">, to pa je priprava </ins>na <ins style="font-weight: bold; text-decoration: none;">poznejšo cepitev glukoze</ins>, <ins style="font-weight: bold; text-decoration: none;">ki celicam zagotavlja </ins>energijo.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Fosforilacija <del style="font-weight: bold; text-decoration: none;">heksoze </del>kot glukoza pogosto omejuje<del style="font-weight: bold; text-decoration: none;">, da bi število znotrajceličnih presnovnih procesov</del>, kot so glikoliza ali <del style="font-weight: bold; text-decoration: none;">sintezo </del>glikogena. Fosforilacija <del style="font-weight: bold; text-decoration: none;">naredi hexose </del>da se ne more <del style="font-weight: bold; text-decoration: none;">premakniti ali odpeljati </del>iz celice.   </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Fosforilacija <ins style="font-weight: bold; text-decoration: none;">heksoz </ins>kot <ins style="font-weight: bold; text-decoration: none;">je </ins>glukoza pogosto omejuje <ins style="font-weight: bold; text-decoration: none;">številne znotrajcelične presnovne procese</ins>, kot so glikoliza ali <ins style="font-weight: bold; text-decoration: none;">sinteza </ins>glikogena. Fosforilacija <ins style="font-weight: bold; text-decoration: none;"> heksoze povzroči, </ins>da se ne more <ins style="font-weight: bold; text-decoration: none;">transportirati </ins>iz celice.   </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Obstajajo <del style="font-weight: bold; text-decoration: none;">štiri za sesalce pomembne heksokinaza izoencimov</del>, ki se razlikujejo po lokacijah in <del style="font-weight: bold; text-decoration: none;">obmolekulski </del>kinetiki glede na <del style="font-weight: bold; text-decoration: none;">različne podlage </del>in <del style="font-weight: bold; text-decoration: none;">pogoje, </del>ter fiziološke funkcije. Ti so imenovani <del style="font-weight: bold; text-decoration: none;">heksokinaze </del>I, II, III in IV ali <del style="font-weight: bold; text-decoration: none;">heksokinaze  </del>A, B, C in D.  </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Obstajajo <ins style="font-weight: bold; text-decoration: none;">štirje izoencimi heksokinaze</ins>, ki se razlikujejo po lokacijah in kinetiki glede na <ins style="font-weight: bold; text-decoration: none;">različnih substratov </ins>in <ins style="font-weight: bold; text-decoration: none;">pogojev delovanja </ins>ter fiziološke funkcije. Ti so imenovani <ins style="font-weight: bold; text-decoration: none;">heksokinaza </ins>I, II, III in IV ali <ins style="font-weight: bold; text-decoration: none;">heksokinaza </ins>A, B, C in D.  </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Heksokinaze I, II in III se lahko <del style="font-weight: bold; text-decoration: none;">fizično pridružijo </del>na zunanjo površino zunanje membrane mitohondrija <del style="font-weight: bold; text-decoration: none;">z posebnimi vezavami </del>na <del style="font-weight: bold; text-decoration: none;">Porin </del>ali napetostno <del style="font-weight: bold; text-decoration: none;">odvisnih kanalov anion</del>.<del style="font-weight: bold; text-decoration: none;"> To združenje podeljuje </del>heksokinazi neposreden dostop do ATP, ki ga mitohondriji<del style="font-weight: bold; text-decoration: none;">, ki je eden od dveh substratov </del>heksokinaze<del style="font-weight: bold; text-decoration: none;">, proizvaja. Mitohondrijska heksokinaza </del>je zelo povišana v hitro rastočih malignih tumorskih <del style="font-weight: bold; text-decoration: none;">celicicah</del>, <del style="font-weight: bold; text-decoration: none;">z nivoji </del>do 200-krat višje <del style="font-weight: bold; text-decoration: none;">od </del>normalnih <del style="font-weight: bold; text-decoration: none;">tkiv. Mitohondrijskih vezanih heksokinaz je bilo dokazano, da je gonilna sila za izjemno visoko glicolitični tečaji, ki potekajo aerobno v tumorskih celicah (tako imenovane Warburg opisanega učinka)</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Heksokinaze I, II in III se lahko <ins style="font-weight: bold; text-decoration: none;">pritrdijo </ins>na zunanjo površino zunanje membrane mitohondrija<ins style="font-weight: bold; text-decoration: none;">, tako da se povežejo </ins>na <ins style="font-weight: bold; text-decoration: none;">[[porin]] </ins>ali napetostno <ins style="font-weight: bold; text-decoration: none;">odvisne anionske kanale</ins>.<ins style="font-weight: bold; text-decoration: none;"> Ta vezava omogoča </ins>heksokinazi neposreden dostop do ATP, ki ga mitohondriji <ins style="font-weight: bold; text-decoration: none;">proizvajajo. Raven mitohondrijske </ins>heksokinaze je zelo povišana v hitro rastočih malignih tumorskih <ins style="font-weight: bold; text-decoration: none;">celicah</ins>, <ins style="font-weight: bold; text-decoration: none;">kjer so ravni </ins>do 200-krat višje <ins style="font-weight: bold; text-decoration: none;">kot v </ins>normalnih <ins style="font-weight: bold; text-decoration: none;">tkivih</ins>.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Povezava</del>:</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">'''Viri</ins>:<ins style="font-weight: bold; text-decoration: none;">'''</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>http://en.wikipedia.org/wiki/Hexokinase  </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>http://en.wikipedia.org/wiki/Hexokinase  </div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>http://www3.interscience.wiley.com:8100/legacy/college/boyer/0471661791/structure/hexokinase/hexokinase.htm</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Viri:</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">http://en.wikipedia.org/wiki/Hexokinase </del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>http://www3.interscience.wiley.com:8100/legacy/college/boyer/0471661791/structure/hexokinase/hexokinase.htm</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td></tr> </table>

MDolinar https://wiki.fkkt.uni-lj.si/index.php?title=Heksokinaza&diff=3063&oldid=prev 2010-02-19T10:57:03Z

<p><a href="/index.php?title=HEKSOKINAZA&amp;action=edit&amp;redlink=1" class="new" title="HEKSOKINAZA (page does not exist)">HEKSOKINAZA</a> moved to <a href="/index.php?title=Heksokinaza" title="Heksokinaza">Heksokinaza</a>: velike črke</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <tr class="diff-title" lang="en"> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:57, 19 February 2010</td> </tr><tr><td colspan="2" class="diff-notice" lang="en"><div class="mw-diff-empty">(No difference)</div> </td></tr></table>

MDolinar https://wiki.fkkt.uni-lj.si/index.php?title=Heksokinaza&diff=3062&oldid=prev 2010-02-19T10:56:37Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:56, 19 February 2010</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l23">Line 23:</td> <td colspan="2" class="diff-lineno">Line 23:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>http://www3.interscience.wiley.com:8100/legacy/college/boyer/0471661791/structure/hexokinase/hexokinase.htm</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>http://www3.interscience.wiley.com:8100/legacy/college/boyer/0471661791/structure/hexokinase/hexokinase.htm</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:LEX]]</ins></div></td></tr> </table>

MDolinar https://wiki.fkkt.uni-lj.si/index.php?title=Heksokinaza&diff=2438&oldid=prev 2010-01-05T10:18:17Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:18, 5 January 2010</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l14">Line 14:</td> <td colspan="2" class="diff-lineno">Line 14:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Povezava:</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Povezava:</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>http://en.wikipedia.org/wiki/Hexokinase  </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>http://en.wikipedia.org/wiki/Hexokinase  </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> </table>

Azagar https://wiki.fkkt.uni-lj.si/index.php?title=Heksokinaza&diff=2423&oldid=prev 2010-01-05T09:59:03Z

<p>Heksokinaza movž</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Heksokinaza&#039;&#039;&#039;<br /> <br /> <br /> Heksokinaza je encim, ki fosforilizira šest-ogljikov sladkor, heksozo, nastane hekso fosfat. V večini tkiv in organizmov, je glukoza najpomembnejši substrat heksokinaze, in glukoza-6-fosfat najpomembnejši produkt. <br /> <br /> Glukoza je edinstvena v tem, da se lahko uporablja kot vir energije, ki ga vse celice uporabljajo v navzočnosti ali ob odsotnosti molekularnega kisika (O2). Glukoza presnovo preko presnovne poti znana kot glikoliza, je pomembno povezano z mitohondrijskimi oksidativnimi presnovami v prisotnosti kisika, ampak lahko tudi glikoliza ustvarja ATP v odsotnosti. Prvi korak v tem zaporedju reakcij je fosforilacija glukoze, heksokinaza za pripravo na poznejše razdelitve, da se zagotovi energijo.<br /> <br /> Fosforilacija heksoze kot glukoza pogosto omejuje, da bi število znotrajceličnih presnovnih procesov, kot so glikoliza ali sintezo glikogena. Fosforilacija naredi hexose da se ne more premakniti ali odpeljati iz celice. <br /> <br /> Obstajajo štiri za sesalce pomembne heksokinaza izoencimov, ki se razlikujejo po lokacijah in obmolekulski kinetiki glede na različne podlage in pogoje, ter fiziološke funkcije. Ti so imenovani heksokinaze I, II, III in IV ali heksokinaze A, B, C in D. <br /> <br /> Heksokinaze I, II in III se lahko fizično pridružijo na zunanjo površino zunanje membrane mitohondrija z posebnimi vezavami na Porin ali napetostno odvisnih kanalov anion. To združenje podeljuje heksokinazi neposreden dostop do ATP, ki ga mitohondriji, ki je eden od dveh substratov heksokinaze, proizvaja. Mitohondrijska heksokinaza je zelo povišana v hitro rastočih malignih tumorskih celicicah, z nivoji do 200-krat višje od normalnih tkiv. Mitohondrijskih vezanih heksokinaz je bilo dokazano, da je gonilna sila za izjemno visoko glicolitični tečaji, ki potekajo aerobno v tumorskih celicah (tako imenovane Warburg opisanega učinka).<br /> <br /> <br /> Povezava:<br /> http://en.wikipedia.org/wiki/Hexokinase <br /> <br /> <br /> Viri:<br /> <br /> http://en.wikipedia.org/wiki/Hexokinase <br /> <br /> http://www3.interscience.wiley.com:8100/legacy/college/boyer/0471661791/structure/hexokinase/hexokinase.htm</div>

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