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Huntingtonova bolezen - Revision history
2026-04-07T07:42:20Z
Revision history for this page on the wiki
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https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=4197&oldid=prev
MDolinar: /* Viri in literatura */
2010-10-22T13:52:40Z
<p><span dir="auto"><span class="autocomment">Viri in literatura</span></span></p>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=1098&oldid=prev
S.Pintar at 18:11, 30 November 2009
2009-11-30T18:11:42Z
<p></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Značilne so tri vrste simptomov: </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Značilne so tri vrste simptomov: </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*fizični, predvsem motorični (horea[[http://www.youtube.com/watch?v=OveGZdZ_sVs video 1]]-sunkoviti nekontrolirani gibi telesa, trzanje, slabljenje mišic in posledično sključena drža, nestabilna hoja, kasneje težave pri govoru in požiranju)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*fizični, predvsem motorični (horea [[http://www.youtube.com/watch?v=OveGZdZ_sVs video 1]]-sunkoviti nekontrolirani gibi telesa, trzanje, slabljenje mišic in posledično sključena drža, nestabilna hoja, kasneje težave pri govoru in požiranju)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*kognitivni (prizadeta zmožnost načrtovanja, organizacije in pomnjenja, ...)</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*kognitivni (prizadeta zmožnost načrtovanja, organizacije in pomnjenja, ...)</div></td></tr>
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S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=1097&oldid=prev
S.Pintar at 18:11, 30 November 2009
2009-11-30T18:11:15Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntingtonova bolezen (HB, angleško HD) je neozdravljiva nevrodegenerativna genetska okvara, ki vpliva na mišično koordinacijo in na nekatere kognitivne funckije. Ponavadi se znaki pojavijo v srednjih letih (med 35. in 44. letom), a pri redki obliki (Westphalova oblika) se simptomi začnejo kazati že pred 20. letom.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntingtonova bolezen (HB, angleško HD) je neozdravljiva nevrodegenerativna genetska okvara, ki vpliva na mišično koordinacijo in na nekatere kognitivne funckije. Ponavadi se znaki pojavijo v srednjih letih (med 35. in 44. letom), a pri redki obliki (Westphalova oblika) se simptomi začnejo kazati že pred 20. letom.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>HB je posledica dominantne mutacije na enem od alelov gena za protein huntingin, ki se nahaja na kromosomu 4. Zaradi mutacije se sintetizira drugačna oblika proteina, ki postopoma vedno huje [http://en.wikipedia.org/wiki/File:Neuron_with_mHtt_inclusion.jpg <del style="font-weight: bold; text-decoration: none;">poškoduje specifične dele možganov</del>]. Z genetskim testiranjem lahko ugotovimo prisotnost mutacije, še pred pojavom simptomov (tudi prenatalno).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>HB je posledica dominantne mutacije na enem od alelov gena za protein huntingin, ki se nahaja na kromosomu 4. Zaradi mutacije se sintetizira drugačna oblika proteina, ki postopoma vedno huje <ins style="font-weight: bold; text-decoration: none;"> poškoduje specifične dele možganov </ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[</ins>[http://en.wikipedia.org/wiki/File:Neuron_with_mHtt_inclusion.jpg <ins style="font-weight: bold; text-decoration: none;">slika 1]</ins>]. Z genetskim testiranjem lahko ugotovimo prisotnost mutacije, še pred pojavom simptomov (tudi prenatalno).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Simptomi ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Simptomi ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Značilne so tri vrste simptomov: </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Značilne so tri vrste simptomov: </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*fizični, predvsem motorični ([http://www.youtube.com/watch?v=OveGZdZ_sVs <del style="font-weight: bold; text-decoration: none;">horea</del>]-sunkoviti nekontrolirani gibi telesa, trzanje, slabljenje mišic in posledično sključena drža, nestabilna hoja, kasneje težave pri govoru in požiranju)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*fizični, predvsem motorični (<ins style="font-weight: bold; text-decoration: none;">horea[</ins>[http://www.youtube.com/watch?v=OveGZdZ_sVs <ins style="font-weight: bold; text-decoration: none;">video 1]</ins>]-sunkoviti nekontrolirani gibi telesa, trzanje, slabljenje mišic in posledično sključena drža, nestabilna hoja, kasneje težave pri govoru in požiranju)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*kognitivni (prizadeta zmožnost načrtovanja, organizacije in pomnjenja, ...)</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*kognitivni (prizadeta zmožnost načrtovanja, organizacije in pomnjenja, ...)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*psihiatrični (demenca, čustvene motnje, razdražljivost, anksioznost, depresija ...)</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*psihiatrični (demenca, čustvene motnje, razdražljivost, anksioznost, depresija ...)</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Genetika===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Genetika===</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Vsi ljudje imamo gen za protein huntingtin (HTT), ki leži na krajšem kraku četrtega kromosoma in del tega gena je ponavljajoče zaporedje treh nukleotidov - citozina, adenina in gvanina (CAG). Dolžina zaporedja se razlikuje pri vsakem posamezniku, vendar načeloma ne presega 28 - 36 ponovitev. Kadar pa se zgodi, da je število ponovitev preveliko, v celicah nastaja mutirana oblika proteina huntingtina (mHTT), ki vodi do pojava Huntingtonove bolezni. Večje kot je število ponovitev, prej se bodo pojavili simptomi bolezni, težji bodo in prej bo sledila smrt. Bolezen se deduje dominantno, kar pomeni, da imajo [http://en.wikipedia.org/wiki/File:Autosomal_Dominant_Pedigree_Chart2.svg <del style="font-weight: bold; text-decoration: none;">otroci z enim prizadetim staršem 50% možnosti, da so podedovali okvarjen gen</del>].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Vsi ljudje imamo gen za protein huntingtin (HTT), ki leži na krajšem kraku četrtega kromosoma in del tega gena je ponavljajoče zaporedje treh nukleotidov - citozina, adenina in gvanina (CAG). Dolžina zaporedja se razlikuje pri vsakem posamezniku, vendar načeloma ne presega 28 - 36 ponovitev. Kadar pa se zgodi, da je število ponovitev preveliko, v celicah nastaja mutirana oblika proteina huntingtina (mHTT), ki vodi do pojava Huntingtonove bolezni. Večje kot je število ponovitev, prej se bodo pojavili simptomi bolezni, težji bodo in prej bo sledila smrt. Bolezen se deduje dominantno, kar pomeni, da imajo <ins style="font-weight: bold; text-decoration: none;">otroci z enim prizadetim staršem 50% možnosti, da so podedovali okvarjen gen [</ins>[http://en.wikipedia.org/wiki/File:Autosomal_Dominant_Pedigree_Chart2.svg <ins style="font-weight: bold; text-decoration: none;">slika 2]</ins>].</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Huntingtin===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Huntingtin===</div></td></tr>
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S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=608&oldid=prev
S.Pintar at 19:34, 22 November 2009
2009-11-22T19:34:16Z
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Huntingtonova bolezen (HB, angleško HD) je neozdravljiva nevrodegenerativna genetska okvara, ki vpliva na mišično koordinacijo in na nekatere kognitivne funckije. Ponavadi se znaki pojavijo v srednjih letih (med 35. <del style="font-weight: bold; text-decoration: none;">In </del>44. letom), a pri redki obliki (Westphalova oblika) se simptomi začnejo kazati že pred 20. letom.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Huntingtonova bolezen (HB, angleško HD) je neozdravljiva nevrodegenerativna genetska okvara, ki vpliva na mišično koordinacijo in na nekatere kognitivne funckije. Ponavadi se znaki pojavijo v srednjih letih (med 35. <ins style="font-weight: bold; text-decoration: none;">in </ins>44. letom), a pri redki obliki (Westphalova oblika) se simptomi začnejo kazati že pred 20. letom.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>HB je posledica dominantne mutacije na enem od alelov gena za protein huntingin, ki se nahaja na kromosomu 4. Zaradi mutacije se sintetizira drugačna oblika proteina, ki postopoma vedno huje [http://en.wikipedia.org/wiki/File:Neuron_with_mHtt_inclusion.jpg poškoduje specifične dele možganov]. Z genetskim testiranjem lahko ugotovimo prisotnost mutacije, še pred pojavom simptomov (tudi prenatalno).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>HB je posledica dominantne mutacije na enem od alelov gena za protein huntingin, ki se nahaja na kromosomu 4. Zaradi mutacije se sintetizira drugačna oblika proteina, ki postopoma vedno huje [http://en.wikipedia.org/wiki/File:Neuron_with_mHtt_inclusion.jpg poškoduje specifične dele možganov]. Z genetskim testiranjem lahko ugotovimo prisotnost mutacije, še pred pojavom simptomov (tudi prenatalno).</div></td></tr>
</table>
S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=543&oldid=prev
S.Pintar at 19:30, 21 November 2009
2009-11-21T19:30:16Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:30, 21 November 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Simptomi ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Simptomi ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Značilne so tri vrste simptomov: </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Značilne so tri vrste simptomov: </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*fizični, predvsem motorični (horea-sunkoviti nekontrolirani gibi telesa, trzanje, slabljenje mišic in posledično sključena drža, nestabilna hoja, kasneje težave pri govoru in požiranju)</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*fizični, predvsem motorični (<ins style="font-weight: bold; text-decoration: none;">[http://www.youtube.com/watch?v=OveGZdZ_sVs </ins>horea<ins style="font-weight: bold; text-decoration: none;">]</ins>-sunkoviti nekontrolirani gibi telesa, trzanje, slabljenje mišic in posledično sključena drža, nestabilna hoja, kasneje težave pri govoru in požiranju)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*kognitivni (prizadeta zmožnost načrtovanja, organizacije in pomnjenja, ...)</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*kognitivni (prizadeta zmožnost načrtovanja, organizacije in pomnjenja, ...)</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*psihiatrični (demenca, čustvene motnje, razdražljivost, anksioznost, depresija ...)</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*psihiatrični (demenca, čustvene motnje, razdražljivost, anksioznost, depresija ...)</div></td></tr>
</table>
S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=542&oldid=prev
S.Pintar at 19:27, 21 November 2009
2009-11-21T19:27:20Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:27, 21 November 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Mehanizem ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Mehanizem ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Genetika===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Genetika===</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Vsi ljudje imamo gen za protein huntingtin (HTT), ki leži na krajšem kraku četrtega kromosoma in del tega gena je ponavljajoče zaporedje treh nukleotidov - citozina, adenina in gvanina (CAG). Dolžina zaporedja se razlikuje pri vsakem posamezniku, vendar načeloma ne presega 28 - 36 ponovitev. Kadar pa se zgodi, da je število ponovitev preveliko, v celicah nastaja mutirana oblika proteina huntingtina (mHTT), ki vodi do pojava Huntingtonove bolezni. Večje kot je število ponovitev, prej se bodo pojavili simptomi bolezni, težji bodo in prej bo sledila smrt. Bolezen se deduje dominantno, kar pomeni, da imajo otroci z enim prizadetim staršem 50% možnosti, da so podedovali okvarjen gen.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Vsi ljudje imamo gen za protein huntingtin (HTT), ki leži na krajšem kraku četrtega kromosoma in del tega gena je ponavljajoče zaporedje treh nukleotidov - citozina, adenina in gvanina (CAG). Dolžina zaporedja se razlikuje pri vsakem posamezniku, vendar načeloma ne presega 28 - 36 ponovitev. Kadar pa se zgodi, da je število ponovitev preveliko, v celicah nastaja mutirana oblika proteina huntingtina (mHTT), ki vodi do pojava Huntingtonove bolezni. Večje kot je število ponovitev, prej se bodo pojavili simptomi bolezni, težji bodo in prej bo sledila smrt. Bolezen se deduje dominantno, kar pomeni, da imajo <ins style="font-weight: bold; text-decoration: none;">[http://en.wikipedia.org/wiki/File:Autosomal_Dominant_Pedigree_Chart2.svg </ins>otroci z enim prizadetim staršem 50% možnosti, da so podedovali okvarjen gen<ins style="font-weight: bold; text-decoration: none;">]</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Huntingtin===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Huntingtin===</div></td></tr>
</table>
S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=541&oldid=prev
S.Pintar at 19:25, 21 November 2009
2009-11-21T19:25:57Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:25, 21 November 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntingtonova bolezen (HB, angleško HD) je neozdravljiva nevrodegenerativna genetska okvara, ki vpliva na mišično koordinacijo in na nekatere kognitivne funckije. Ponavadi se znaki pojavijo v srednjih letih (med 35. In 44. letom), a pri redki obliki (Westphalova oblika) se simptomi začnejo kazati že pred 20. letom.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntingtonova bolezen (HB, angleško HD) je neozdravljiva nevrodegenerativna genetska okvara, ki vpliva na mišično koordinacijo in na nekatere kognitivne funckije. Ponavadi se znaki pojavijo v srednjih letih (med 35. In 44. letom), a pri redki obliki (Westphalova oblika) se simptomi začnejo kazati že pred 20. letom.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>HB je posledica dominantne mutacije na enem od alelov gena za protein huntingin, ki se nahaja na kromosomu 4. Zaradi mutacije se sintetizira drugačna oblika proteina, ki postopoma vedno huje poškoduje specifične dele možganov. Z genetskim testiranjem lahko ugotovimo prisotnost mutacije, še pred pojavom simptomov (tudi prenatalno).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>HB je posledica dominantne mutacije na enem od alelov gena za protein huntingin, ki se nahaja na kromosomu 4. Zaradi mutacije se sintetizira drugačna oblika proteina, ki postopoma vedno huje <ins style="font-weight: bold; text-decoration: none;">[http://en.wikipedia.org/wiki/File:Neuron_with_mHtt_inclusion.jpg </ins>poškoduje specifične dele možganov<ins style="font-weight: bold; text-decoration: none;">]</ins>. Z genetskim testiranjem lahko ugotovimo prisotnost mutacije, še pred pojavom simptomov (tudi prenatalno).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Simptomi ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Simptomi ==</div></td></tr>
</table>
S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=540&oldid=prev
S.Pintar at 19:23, 21 November 2009
2009-11-21T19:23:31Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:23, 21 November 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>*Huntington's disease.[citirano 21.11.2009] http://en.wikipedia.org/<del style="font-weight: bold; text-decoration: none;">w</del>/<del style="font-weight: bold; text-decoration: none;">index.php?title=</del>Huntington%27s_disease<del style="font-weight: bold; text-decoration: none;">&oldid=326931097</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>*Huntington's disease.[citirano 21.11.2009] http://en.wikipedia.org/<ins style="font-weight: bold; text-decoration: none;">wiki</ins>/Huntington%27s_disease</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Huntingtin. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntingtin</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Huntingtin. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntingtin</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Huntington's disease clinical research. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntington%27s_disease_clinical_research</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Huntington's disease clinical research. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntington%27s_disease_clinical_research</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Psihiatrični vidiki Huntingove bolezni - prikaz primerov. 26.11.2003 [citirano 21.11.2009] http://vestnik.szd.si/st4-4/st4-4-239-242.htm</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Psihiatrični vidiki Huntingove bolezni - prikaz primerov. 26.11.2003 [citirano 21.11.2009] http://vestnik.szd.si/st4-4/st4-4-239-242.htm</div></td></tr>
</table>
S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=539&oldid=prev
S.Pintar at 19:20, 21 November 2009
2009-11-21T19:20:38Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:20, 21 November 2009</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Huntington's disease.[citirano 21.11.2009] http://en.wikipedia.org/w/index.php?title=Huntington%27s_disease&oldid=326931097</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*</ins>Huntington's disease.[citirano 21.11.2009] http://en.wikipedia.org/w/index.php?title=Huntington%27s_disease&oldid=326931097</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*</ins>Huntingtin. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntingtin</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Huntingtin. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntingtin</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*</ins>Huntington's disease clinical research. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntington%27s_disease_clinical_research</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*</ins>Psihiatrični vidiki Huntingove bolezni - prikaz primerov. 26.11.2003 [citirano 21.11.2009] http://vestnik.szd.si/st4-4/st4-4-239-242.htm</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Huntington's disease clinical research. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntington%27s_disease_clinical_research</div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Psihiatrični vidiki Huntingove bolezni - prikaz primerov. 26.11.2003 [citirano 21.11.2009] http://vestnik.szd.si/st4-4/st4-4-239-242.htm</div></td><td colspan="2" class="diff-side-added"></td></tr>
</table>
S.Pintar
https://wiki.fkkt.uni-lj.si/index.php?title=Huntingtonova_bolezen&diff=538&oldid=prev
S.Pintar at 19:19, 21 November 2009
2009-11-21T19:19:22Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:19, 21 November 2009</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l26">Line 26:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntington's disease.[citirano 21.11.2009] http://en.wikipedia.org/w/index.php?title=Huntington%27s_disease&oldid=326931097</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntington's disease.[citirano 21.11.2009] http://en.wikipedia.org/w/index.php?title=Huntington%27s_disease&oldid=326931097</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntingtin. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntingtin</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntingtin. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntingtin</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntington's disease clinical research. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntington%27s_disease_clinical_research</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Huntington's disease clinical research. [citirano 21.11.2009] http://en.wikipedia.org/wiki/Huntington%27s_disease_clinical_research</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psihiatrični vidiki Huntingove bolezni - prikaz primerov. 26.11.2003 [citirano 21.11.2009] http://vestnik.szd.si/st4-4/st4-4-239-242.htm</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Psihiatrični vidiki Huntingove bolezni - prikaz primerov. 26.11.2003 [citirano 21.11.2009] http://vestnik.szd.si/st4-4/st4-4-239-242.htm</div></td></tr>
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S.Pintar