https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Katepsin_C 2026-05-23T13:06:40Z Revision history for this page on the wiki MediaWiki 1.45.3 https://wiki.fkkt.uni-lj.si/index.php?title=Katepsin_C&diff=3021&oldid=prev 2010-01-29T11:54:07Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:54, 29 January 2010</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Katepsin C oziroma dipeptidilpetidaza l je [http://sl.wikipedia.org/wiki/Lizosom lizosomska] [http://en.wikipedia.org/wiki/Cysteine_protease cisteinska proteaza]<del style="font-weight: bold; text-decoration: none;">, </del>iz peptidazne družine C1. Po svoji aktivnosti je eksopeptidaza. Gen pri človeku ima oznako CTSC.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Katepsin C oziroma dipeptidilpetidaza l je [http://sl.wikipedia.org/wiki/Lizosom lizosomska] [http://en.wikipedia.org/wiki/Cysteine_protease cisteinska proteaza] iz peptidazne družine C1. Po svoji aktivnosti je eksopeptidaza. Gen pri človeku ima oznako CTSC.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Funkcija==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Funkcija==</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l6">Line 6:</td> <td colspan="2" class="diff-lineno">Line 6:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Struktura==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Struktura==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Na osnovi nukleotidnih zaporedij zapisov za katepsine C podgan, človeka, miši, goveda, psa in parazita [http://en.wikipedia.org/wiki/Schistosome Schistosoma] so ugotovili, da je encim zelo ohranjen. Človeški in podganji <del style="font-weight: bold; text-decoration: none;">Katepsin </del>C <del style="font-weight: bold; text-decoration: none;">cDNAs kodiranje predhodnikov (prepro-Katepsin C)</del>, ki <del style="font-weight: bold; text-decoration: none;">vsebuje signal peptida </del>24 ostankov, pro-<del style="font-weight: bold; text-decoration: none;">regijah </del>205 (podganji <del style="font-weight: bold; text-decoration: none;">Katepsin C</del>) <del style="font-weight: bold; text-decoration: none;">ali </del>206 (<del style="font-weight: bold; text-decoration: none;">človeski Katepsin </del>C) <del style="font-weight: bold; text-decoration: none;">ostankov </del>in <del style="font-weight: bold; text-decoration: none;">katalitskih področij </del>233 ostankov<del style="font-weight: bold; text-decoration: none;">, ki vsebujejo ostanke katalitskega in so </del>30-40% <del style="font-weight: bold; text-decoration: none;">enak zrela zaporedja amino kisline papain </del>in <del style="font-weight: bold; text-decoration: none;">številko </del>drugih <del style="font-weight: bold; text-decoration: none;">Katepsinov, vključno Katepsini, </del>B, H, K, L, in S. <del style="font-weight: bold; text-decoration: none;">Prevedena prepro</del>-<del style="font-weight: bold; text-decoration: none;">Katepsin </del>C se <del style="font-weight: bold; text-decoration: none;">predela </del>v <del style="font-weight: bold; text-decoration: none;">zreli obliki z </del>vsaj <del style="font-weight: bold; text-decoration: none;">štirimi razcepi polipeptidnih verig</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Na osnovi nukleotidnih zaporedij zapisov <ins style="font-weight: bold; text-decoration: none;">(cDNA) </ins>za katepsine C podgan, človeka, miši, goveda, psa in parazita [http://en.wikipedia.org/wiki/Schistosome Schistosoma] so ugotovili, da je encim zelo ohranjen. Človeški in podganji <ins style="font-weight: bold; text-decoration: none;">katepsin </ins>C <ins style="font-weight: bold; text-decoration: none;">se sintetizirata kot preproencima</ins>, ki <ins style="font-weight: bold; text-decoration: none;">vsebujeta signalni peptid dolg </ins>24 ostankov, pro-<ins style="font-weight: bold; text-decoration: none;">regijo z </ins>205 (podganji) <ins style="font-weight: bold; text-decoration: none;">oziroma z </ins>206 <ins style="font-weight: bold; text-decoration: none;"> ostanki</ins>(<ins style="font-weight: bold; text-decoration: none;">človeški katepsin </ins>C) in <ins style="font-weight: bold; text-decoration: none;">katalitsko področje dolgo </ins>233 <ins style="font-weight: bold; text-decoration: none;">aminokislinskih </ins>ostankov<ins style="font-weight: bold; text-decoration: none;">. Med temi jih je </ins>30-40 % <ins style="font-weight: bold; text-decoration: none;">identičnih kot v zaporedju encima papaina </ins>in <ins style="font-weight: bold; text-decoration: none;">številnih </ins>drugih <ins style="font-weight: bold; text-decoration: none;">katepsinov (</ins>B, H, K, L, in S<ins style="font-weight: bold; text-decoration: none;">)</ins>. <ins style="font-weight: bold; text-decoration: none;">Prepro</ins>-<ins style="font-weight: bold; text-decoration: none;">katepsin </ins>C se <ins style="font-weight: bold; text-decoration: none;">pretvori </ins>v <ins style="font-weight: bold; text-decoration: none;"> zrelo obliko po </ins>vsaj <ins style="font-weight: bold; text-decoration: none;">štirih cepitvah polipeptidne verige</ins>.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri in literatura==</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*http://en.wikipedia.org/wiki/Cathepsin_C</ins></div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*http://www.nature.com/emboj/journal/v20/n23/full/7594146a.html</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*http://www.nature.com/emboj/journal/v20/n23/full/7594146a.html</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">*http://en.wikipedia.org/wiki/Cathepsin_C</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td></tr> </table>

MDolinar https://wiki.fkkt.uni-lj.si/index.php?title=Katepsin_C&diff=3020&oldid=prev 2010-01-29T11:23:01Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:23, 29 January 2010</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Katepsin C oziroma <del style="font-weight: bold; text-decoration: none;">dipeptidna petidaza </del>l je [http://sl.wikipedia.org/wiki/Lizosom lizosomska] <del style="font-weight: bold; text-decoration: none;">exo-</del>[http://en.wikipedia.org/wiki/Cysteine_protease <del style="font-weight: bold; text-decoration: none;">cistein </del>proteaza], <del style="font-weight: bold; text-decoration: none;">ki pripadajo peptidazni </del>C1 <del style="font-weight: bold; text-decoration: none;">družini</del>. <del style="font-weight: bold; text-decoration: none;">Pri ljudeh </del>je <del style="font-weight: bold; text-decoration: none;">znan kot </del>CTSC <del style="font-weight: bold; text-decoration: none;">gene</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Katepsin C oziroma <ins style="font-weight: bold; text-decoration: none;">dipeptidilpetidaza </ins>l je [http://sl.wikipedia.org/wiki/Lizosom lizosomska] [http://en.wikipedia.org/wiki/Cysteine_protease <ins style="font-weight: bold; text-decoration: none;">cisteinska </ins>proteaza], <ins style="font-weight: bold; text-decoration: none;">iz peptidazne družine </ins>C1. <ins style="font-weight: bold; text-decoration: none;">Po svoji aktivnosti </ins>je <ins style="font-weight: bold; text-decoration: none;">eksopeptidaza. Gen pri človeku ima oznako </ins>CTSC.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Funkcija==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Funkcija==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Zgleda, da je </del>Katepsin C <del style="font-weight: bold; text-decoration: none;">osrednji  koordinator za aktiviranje </del>mnogih [http://en.wikipedia.org/wiki/Serine_protease serinskih proteaz] v imunskih / vnetnih <del style="font-weight: bold; text-decoration: none;">celic</del>. <del style="font-weight: bold; text-decoration: none;">Cathepsin C katalizira izrez </del>dipeptidov <del style="font-weight: bold; text-decoration: none;">iz </del>[http://en.wikipedia.org/wiki/N-terminal N-<del style="font-weight: bold; text-decoration: none;">terminalnih</del>]<del style="font-weight: bold; text-decoration: none;">beljakovin </del>in peptidnih substratov, razen če je (i) <del style="font-weight: bold; text-decoration: none;">amino </del>skupina N-<del style="font-weight: bold; text-decoration: none;">terminalnem </del>blokirana, (ii) mesto cepitve <del style="font-weight: bold; text-decoration: none;">na obeh straneh prolina ostankov</del>, ( iii) N-<del style="font-weight: bold; text-decoration: none;">terminal </del>ostanek ali <del style="font-weight: bold; text-decoration: none;">lizin </del>arginin, ali (iv) struktura peptida ali beljakovine<del style="font-weight: bold; text-decoration: none;">, ki </del>preprečuje nadaljnje <del style="font-weight: bold; text-decoration: none;">prebave iz </del>N-<del style="font-weight: bold; text-decoration: none;">terminalnega</del>. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Katepsin C <ins style="font-weight: bold; text-decoration: none;">je pomemben aktivator </ins>mnogih [http://en.wikipedia.org/wiki/Serine_protease serinskih proteaz] v imunskih / vnetnih <ins style="font-weight: bold; text-decoration: none;">celicah</ins>. <ins style="font-weight: bold; text-decoration: none;">Katalizira odcep </ins>dipeptidov <ins style="font-weight: bold; text-decoration: none;">z </ins>[http://en.wikipedia.org/wiki/N-terminal N-<ins style="font-weight: bold; text-decoration: none;">koncev</ins>] <ins style="font-weight: bold; text-decoration: none;">beljakovinskih </ins>in peptidnih substratov, razen če je (i) <ins style="font-weight: bold; text-decoration: none;">aminska </ins>skupina <ins style="font-weight: bold; text-decoration: none;">na </ins>N-<ins style="font-weight: bold; text-decoration: none;">koncu </ins>blokirana, (ii) mesto cepitve <ins style="font-weight: bold; text-decoration: none;">pred ali za prolinskim ostankom</ins>, ( iii) N-<ins style="font-weight: bold; text-decoration: none;">končni </ins>ostanek <ins style="font-weight: bold; text-decoration: none;">lizin </ins>ali arginin, ali (iv) struktura peptida ali beljakovine preprečuje nadaljnje <ins style="font-weight: bold; text-decoration: none;">odcepljanje dipeptidov z </ins>N-<ins style="font-weight: bold; text-decoration: none;">konca</ins>. </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Struktura==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Struktura==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">CDNAs kodiranje </del>podgan, človeka, miši, goveda, psa in <del style="font-weight: bold; text-decoration: none;">dve </del>[http://en.wikipedia.org/wiki/Schistosome <del style="font-weight: bold; text-decoration: none;">Schistosome</del>] <del style="font-weight: bold; text-decoration: none;">Cs Katepsin </del>so <del style="font-weight: bold; text-decoration: none;">klonirali in razvrstili</del>, <del style="font-weight: bold; text-decoration: none;">in kaže </del>da <del style="font-weight: bold; text-decoration: none;">so </del>encim zelo <del style="font-weight: bold; text-decoration: none;">ohranjeni</del>. Človeški in podganji Katepsin C cDNAs kodiranje predhodnikov (prepro-Katepsin C), ki vsebuje signal peptida 24 ostankov, pro-regijah 205 (podganji Katepsin C) ali 206 (človeski Katepsin C) ostankov in katalitskih področij 233 ostankov, ki vsebujejo ostanke katalitskega in so 30-40% enak zrela zaporedja amino kisline papain in številko drugih Katepsinov, vključno Katepsini, B, H, K, L, in S. Prevedena prepro-Katepsin C se predela v zreli obliki z vsaj štirimi razcepi polipeptidnih verig.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Na osnovi nukleotidnih zaporedij zapisov za katepsine C </ins>podgan, človeka, miši, goveda, psa in <ins style="font-weight: bold; text-decoration: none;">parazita </ins>[http://en.wikipedia.org/wiki/Schistosome <ins style="font-weight: bold; text-decoration: none;">Schistosoma</ins>] so <ins style="font-weight: bold; text-decoration: none;">ugotovili</ins>, da <ins style="font-weight: bold; text-decoration: none;">je </ins>encim zelo <ins style="font-weight: bold; text-decoration: none;">ohranjen</ins>. Človeški in podganji Katepsin C cDNAs kodiranje predhodnikov (prepro-Katepsin C), ki vsebuje signal peptida 24 ostankov, pro-regijah 205 (podganji Katepsin C) ali 206 (človeski Katepsin C) ostankov in katalitskih področij 233 ostankov, ki vsebujejo ostanke katalitskega in so 30-40% enak zrela zaporedja amino kisline papain in številko drugih Katepsinov, vključno Katepsini, B, H, K, L, in S. Prevedena prepro-Katepsin C se predela v zreli obliki z vsaj štirimi razcepi polipeptidnih verig.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> </table>

MDolinar https://wiki.fkkt.uni-lj.si/index.php?title=Katepsin_C&diff=3016&oldid=prev 2010-01-29T11:09:05Z

<p><a href="/index.php?title=Katepsin_c" class="mw-redirect" title="Katepsin c">Katepsin c</a> moved to <a href="/index.php?title=Katepsin_C" title="Katepsin C">Katepsin C</a>: veliki C</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <tr class="diff-title" lang="en"> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="1" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:09, 29 January 2010</td> </tr><tr><td colspan="2" class="diff-notice" lang="en"><div class="mw-diff-empty">(No difference)</div> </td></tr></table>

MDolinar https://wiki.fkkt.uni-lj.si/index.php?title=Katepsin_C&diff=2250&oldid=prev 2010-01-04T22:19:11Z

<p>New page: Katepsin C oziroma dipeptidna petidaza l je [http://sl.wikipedia.org/wiki/Lizosom lizosomska] exo-[http://en.wikipedia.org/wiki/Cysteine_protease cistein proteaza], ki pripadajo peptidazni...</p> <p><b>New page</b></p><div>Katepsin C oziroma dipeptidna petidaza l je [http://sl.wikipedia.org/wiki/Lizosom lizosomska] exo-[http://en.wikipedia.org/wiki/Cysteine_protease cistein proteaza], ki pripadajo peptidazni C1 družini. Pri ljudeh je znan kot CTSC gene.<br /> <br /> ==Funkcija==<br /> Zgleda, da je Katepsin C osrednji koordinator za aktiviranje mnogih [http://en.wikipedia.org/wiki/Serine_protease serinskih proteaz] v imunskih / vnetnih celic. Cathepsin C katalizira izrez dipeptidov iz [http://en.wikipedia.org/wiki/N-terminal N-terminalnih]beljakovin in peptidnih substratov, razen če je (i) amino skupina N-terminalnem blokirana, (ii) mesto cepitve na obeh straneh prolina ostankov, ( iii) N-terminal ostanek ali lizin arginin, ali (iv) struktura peptida ali beljakovine, ki preprečuje nadaljnje prebave iz N-terminalnega. <br /> <br /> <br /> ==Struktura==<br /> CDNAs kodiranje podgan, človeka, miši, goveda, psa in dve [http://en.wikipedia.org/wiki/Schistosome Schistosome] Cs Katepsin so klonirali in razvrstili, in kaže da so encim zelo ohranjeni. Človeški in podganji Katepsin C cDNAs kodiranje predhodnikov (prepro-Katepsin C), ki vsebuje signal peptida 24 ostankov, pro-regijah 205 (podganji Katepsin C) ali 206 (človeski Katepsin C) ostankov in katalitskih področij 233 ostankov, ki vsebujejo ostanke katalitskega in so 30-40% enak zrela zaporedja amino kisline papain in številko drugih Katepsinov, vključno Katepsini, B, H, K, L, in S. Prevedena prepro-Katepsin C se predela v zreli obliki z vsaj štirimi razcepi polipeptidnih verig.<br /> <br /> <br /> ==Viri in literatura==<br /> *http://www.nature.com/emboj/journal/v20/n23/full/7594146a.html<br /> *http://en.wikipedia.org/wiki/Cathepsin_C<br /> <br /> <br /> [[Category:LEX]]</div>

Igor.Zelenovic