https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Klavulanska_kislina
Klavulanska kislina - Revision history
2026-04-15T22:31:18Z
Revision history for this page on the wiki
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https://wiki.fkkt.uni-lj.si/index.php?title=Klavulanska_kislina&diff=7827&oldid=prev
MDolinar at 14:05, 1 February 2013
2013-02-01T14:05:27Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Kemijske lastnosti===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Kemijske lastnosti===</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Ime po IUPAC-u: (2R,5R,Z)-3-(2-hidroksietiliden)-7-okso-4-oksa-1-aza-biciklo[3.2.0]heptan-2-karboksilna kislina</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*Ime po IUPAC-u: (2R,5R,Z)-3-(2-hidroksietiliden)-7-okso-4-oksa-1-aza-biciklo[3.2.0]heptan-2-karboksilna kislina</div></td></tr>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Klavulanska_kislina&diff=7826&oldid=prev
MDolinar at 14:04, 1 February 2013
2013-02-01T14:04:54Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Slike===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Slike===</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Skeletna formula klavulanske kisline: http://<del style="font-weight: bold; text-decoration: none;">upload</del>.<del style="font-weight: bold; text-decoration: none;">wikimedia</del>.org/<del style="font-weight: bold; text-decoration: none;">wikipedia/commons/b/b4</del>/Clavulanic_acid_structure.svg</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Skeletna formula klavulanske kisline: http://<ins style="font-weight: bold; text-decoration: none;">sl</ins>.<ins style="font-weight: bold; text-decoration: none;">wikipedia</ins>.org/<ins style="font-weight: bold; text-decoration: none;">wiki</ins>/<ins style="font-weight: bold; text-decoration: none;">Slika:</ins>Clavulanic_acid_structure.svg<ins style="font-weight: bold; text-decoration: none;"><br></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kvartarna struktura betalaktamaze: http://en.wikipedia.org/wiki/File:PDB_1bsg_EBI.jpg</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kvartarna struktura betalaktamaze: http://en.wikipedia.org/wiki/File:PDB_1bsg_EBI.jpg</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* http://www.jbc.org/content/281/1/279.long</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* http://www.jbc.org/content/281/1/279.long</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* http://en.wikipedia.org/wiki/Clavulanic_acid</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* http://en.wikipedia.org/wiki/Clavulanic_acid</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* http://sl.wikipedia.org/wiki/Klavulanska_kislina (!)</ins></div></td></tr>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Klavulanska_kislina&diff=7750&oldid=prev
GasperM at 22:18, 6 January 2013
2013-01-06T22:18:23Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:18, 6 January 2013</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Splošno===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Splošno===</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Klavulanska kislina''' je snov iz skupine zaviralcev betalaktamaze. <del style="font-weight: bold; text-decoration: none;">Njeno </del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Klavulanska kislina''' je snov iz skupine zaviralcev betalaktamaze.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>::''<del style="font-weight: bold; text-decoration: none;">Betalaktamaza </del>je encim, ki hidrolizira betalaktam v penicilinih in cefalosporinih in jih deaktivira. Ta encim tvorijo bakterije, ki so odporne proti tovrstnim antibiotikom. Zaviralci betalaktamaz so snovi, ki preprečujejo delovanje tega encima in tako odpornost na antibiotik. Mednje sodita, poleg klavulanske kisline, še Sulbaktam in Tazobaktam.''</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>::''<ins style="font-weight: bold; text-decoration: none;">[[Beta laktamaza]] </ins>je encim, ki hidrolizira betalaktam v penicilinih in cefalosporinih in jih deaktivira. Ta encim tvorijo bakterije, ki so odporne proti tovrstnim antibiotikom. Zaviralci betalaktamaz so snovi, ki preprečujejo delovanje tega encima in tako odpornost na antibiotik. Mednje sodita, poleg klavulanske kisline, še Sulbaktam in Tazobaktam.''</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Klavulanska kislina se uporablja v kombinaciji s penicilinskimi antibiotiki in s tem poveča njihovo učinkovitost. Encim betalaktamaza namreč razgrajuje penicilin, klavulanska kislina pa deaktivira encim betalaktamazo. Danes je veliko sodobnejših penicilinov na ta encim že samih po sebi odpornih. Ponavadi se uporablja kalijeva sol klavulanske kisline, '''kalijev klavulanat'''. Najdemo jo v zdravilih Amoksiklav, Betaklav, Augmentin in Amoksicilin</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Klavulanska kislina se uporablja v kombinaciji s penicilinskimi antibiotiki in s tem poveča njihovo učinkovitost. Encim betalaktamaza namreč razgrajuje penicilin, klavulanska kislina pa deaktivira encim betalaktamazo. Danes je veliko sodobnejših penicilinov na ta encim že samih po sebi odpornih. Ponavadi se uporablja kalijeva sol klavulanske kisline, '''kalijev klavulanat'''. Najdemo jo v zdravilih Amoksiklav, Betaklav, Augmentin in Amoksicilin</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kislina je molekula, ki se v človeškem telesu presnavlja v jetrih in se izloči iz telesa preko ledvic.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kislina je molekula, ki se v človeškem telesu presnavlja v jetrih in se izloči iz telesa preko ledvic.</div></td></tr>
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GasperM
https://wiki.fkkt.uni-lj.si/index.php?title=Klavulanska_kislina&diff=7743&oldid=prev
GasperM: /* Vir */
2013-01-06T22:06:41Z
<p><span dir="auto"><span class="autocomment">Vir</span></span></p>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Vir===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Vir===</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>V naravi to snov proizvaja gliva z latinskim imenom Streptomyces clavuligerus. Po njej je Klavulanska kislina tudi dobila ime. Biosintetsko se sicer tvori iz aminokisline arginin in sladkorja gliceraldehid-3-fosfata.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>V naravi to snov proizvaja gliva z latinskim imenom Streptomyces clavuligerus. Po njej je Klavulanska kislina tudi dobila ime. Biosintetsko se sicer tvori iz aminokisline <ins style="font-weight: bold; text-decoration: none;">[[</ins>arginin<ins style="font-weight: bold; text-decoration: none;">]] </ins>in sladkorja gliceraldehid-3-fosfata.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Odkritje===</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>===Odkritje===</div></td></tr>
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GasperM
https://wiki.fkkt.uni-lj.si/index.php?title=Klavulanska_kislina&diff=7742&oldid=prev
GasperM: New page: ==KLAVULANSKA KISLINA== ===Kemijske lastnosti=== *Ime po IUPAC-u: (2R,5R,Z)-3-(2-hidroksietiliden)-7-okso-4-oksa-1-aza-biciklo[3.2.0]heptan-2-karboksilna kislina *Molekulska formula: C<sub...
2013-01-06T22:03:55Z
<p>New page: ==KLAVULANSKA KISLINA== ===Kemijske lastnosti=== *Ime po IUPAC-u: (2R,5R,Z)-3-(2-hidroksietiliden)-7-okso-4-oksa-1-aza-biciklo[3.2.0]heptan-2-karboksilna kislina *Molekulska formula: C<sub...</p>
<p><b>New page</b></p><div>==KLAVULANSKA KISLINA==<br />
===Kemijske lastnosti===<br />
*Ime po IUPAC-u: (2R,5R,Z)-3-(2-hidroksietiliden)-7-okso-4-oksa-1-aza-biciklo[3.2.0]heptan-2-karboksilna kislina<br />
*Molekulska formula: C<sub>2</sub>H<sub>2</sub>NO<sub>5</sub><br />
*Molska masa: 199,16 g/mol<br />
<br />
===Splošno===<br />
'''Klavulanska kislina''' je snov iz skupine zaviralcev betalaktamaze. Njeno <br />
::''Betalaktamaza je encim, ki hidrolizira betalaktam v penicilinih in cefalosporinih in jih deaktivira. Ta encim tvorijo bakterije, ki so odporne proti tovrstnim antibiotikom. Zaviralci betalaktamaz so snovi, ki preprečujejo delovanje tega encima in tako odpornost na antibiotik. Mednje sodita, poleg klavulanske kisline, še Sulbaktam in Tazobaktam.''<br />
Klavulanska kislina se uporablja v kombinaciji s penicilinskimi antibiotiki in s tem poveča njihovo učinkovitost. Encim betalaktamaza namreč razgrajuje penicilin, klavulanska kislina pa deaktivira encim betalaktamazo. Danes je veliko sodobnejših penicilinov na ta encim že samih po sebi odpornih. Ponavadi se uporablja kalijeva sol klavulanske kisline, '''kalijev klavulanat'''. Najdemo jo v zdravilih Amoksiklav, Betaklav, Augmentin in Amoksicilin<br />
Kislina je molekula, ki se v človeškem telesu presnavlja v jetrih in se izloči iz telesa preko ledvic.<br />
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V ZDA tudi že potekajo klinična preiskušanja uporabe klavulanske kisline kot antidepresiva in afrodiziaka.<br />
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===Vir===<br />
V naravi to snov proizvaja gliva z latinskim imenom Streptomyces clavuligerus. Po njej je Klavulanska kislina tudi dobila ime. Biosintetsko se sicer tvori iz aminokisline arginin in sladkorja gliceraldehid-3-fosfata.<br />
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===Odkritje===<br />
Odkrila jo je britanska farmacevtska družba Beecham med leti 1974 in 1975. Patentno zaščito pa je podjetje, po vlogi leta 1981, dobilo leta 1985.<br />
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===Slike===<br />
Skeletna formula klavulanske kisline: http://upload.wikimedia.org/wikipedia/commons/b/b4/Clavulanic_acid_structure.svg<br />
Kvartarna struktura betalaktamaze: http://en.wikipedia.org/wiki/File:PDB_1bsg_EBI.jpg<br />
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===Viri===<br />
* http://www.jbc.org/content/281/1/279.long<br />
* http://en.wikipedia.org/wiki/Clavulanic_acid<br />
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[[Category:LEX]]</div>
GasperM