https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Laminin
Laminin - Revision history
2026-04-09T12:17:31Z
Revision history for this page on the wiki
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https://wiki.fkkt.uni-lj.si/index.php?title=Laminin&diff=5329&oldid=prev
MDolinar at 09:47, 4 February 2011
2011-02-04T09:47:06Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 09:47, 4 February 2011</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Laminin je glavna povezovalna beljakovina v bazalni lamini (<del style="font-weight: bold; text-decoration: none;">Bazalna lamina </del>je tanka mrežasta struktura, ki celice epitela, mišičnega in živčnega tkiva ločuje od vezivnega tkiva, ki jih obdaja)<del style="font-weight: bold; text-decoration: none;">, ki veže </del>vse elemente bazalne lamine in tako tvori <del style="font-weight: bold; text-decoration: none;">temeljno </del>omrežje za vezavo večine celic in organov. Laminini so biološko aktivnih del bazalne lamine, ki vplivajo na <del style="font-weight: bold; text-decoration: none;">celične diferenciacije</del>, migracije, <del style="font-weight: bold; text-decoration: none;">oprijema</del>, <del style="font-weight: bold; text-decoration: none;">kot </del>tudi fenotip in preživetje.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Laminin je glavna povezovalna beljakovina v bazalni lamini (<ins style="font-weight: bold; text-decoration: none;">to </ins>je tanka mrežasta struktura, ki celice epitela, mišičnega in živčnega tkiva ločuje od vezivnega tkiva, ki jih obdaja)<ins style="font-weight: bold; text-decoration: none;">. Povezuje </ins>vse elemente bazalne lamine in tako tvori omrežje za vezavo večine celic in organov. Laminini so biološko aktivnih del bazalne lamine, ki vplivajo na <ins style="font-weight: bold; text-decoration: none;">celično diferenciacijo</ins>, migracije, <ins style="font-weight: bold; text-decoration: none;">oprijem celic</ins>, <ins style="font-weight: bold; text-decoration: none;">pa </ins>tudi <ins style="font-weight: bold; text-decoration: none;">na njihov </ins>fenotip in preživetje.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== ZGRADBA IN FUNKCIJA ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== ZGRADBA IN FUNKCIJA ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Lamininska molekula je sestavljena iz treh velikih polipeptidov-α, β1 in β2 (γ) povezanih z disulfidnimi mostički. Lamininske molekule so poimenovane glede na njihovo sestavo verige. Tako laminin-511 vsebuje α5, β1 in γ1 (β2) <del style="font-weight: bold; text-decoration: none;">verigo</del>. Obstaja še štirinajst drugih kombinacij verig. Beljakovina je oblike znaka plus z eno dolgo roko<del style="font-weight: bold; text-decoration: none;">. </del>[http://219.221.200.61/ywwy/zbsw(E)/pic/ech4-6.jpg <del style="font-weight: bold; text-decoration: none;">Slika1</del>]Tri krajše roke se vežejo na druge molekule laminina, daljša roka pa se veže na celice in tako pomaga sidrati tkiva. Povezuje pa se tudi s kolagenom<del style="font-weight: bold; text-decoration: none;">.</del>[http://www.sigmaaldrich.com/etc/medialib/life-science/metabolomics/enzyme-explorer/laminin.Par.0001.Image.484.gif <del style="font-weight: bold; text-decoration: none;">Slika2</del>]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Lamininska molekula je sestavljena iz treh velikih polipeptidov-α, β1 in β2 (γ)<ins style="font-weight: bold; text-decoration: none;">, </ins>povezanih z disulfidnimi mostički. Lamininske molekule so poimenovane glede na njihovo sestavo verige. Tako laminin-511 vsebuje <ins style="font-weight: bold; text-decoration: none;">verige </ins>α5, β1 in γ1 (β2). Obstaja še štirinajst drugih kombinacij verig. Beljakovina je oblike znaka plus z eno dolgo roko [http://219.221.200.61/ywwy/zbsw(E)/pic/ech4-6.jpg <ins style="font-weight: bold; text-decoration: none;">- slika</ins>]<ins style="font-weight: bold; text-decoration: none;">. </ins>Tri krajše roke se vežejo na druge molekule laminina, daljša roka pa se veže na celice in tako pomaga sidrati tkiva. Povezuje pa se tudi s kolagenom [http://www.sigmaaldrich.com/etc/medialib/life-science/metabolomics/enzyme-explorer/laminin.Par.0001.Image.484.gif <ins style="font-weight: bold; text-decoration: none;">- slika</ins>]<ins style="font-weight: bold; text-decoration: none;">.</ins></div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8">Line 8:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Laminini so kombinacije različnih alfa-, beta-in gama-verig.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Laminini so kombinacije različnih alfa-, beta-in gama-verig.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del>* Obstaja pet oblik alfa verige: [http://en.wikipedia.org/wiki/LAMA1 LAMA1], [http://en.wikipedia.org/wiki/LAMA2 LAMA2], [http://en.wikipedia.org/wiki/LAMA3 LAMA3], [http://en.wikipedia.org/wiki/LAMA4 LAMA4], [http://en.wikipedia.org/wiki/LAMA5 LAMA5]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Obstaja pet oblik alfa verige: [http://en.wikipedia.org/wiki/LAMA1 LAMA1], [http://en.wikipedia.org/wiki/LAMA2 LAMA2], [http://en.wikipedia.org/wiki/LAMA3 LAMA3], [http://en.wikipedia.org/wiki/LAMA4 LAMA4], [http://en.wikipedia.org/wiki/LAMA5 LAMA5]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del>* Obstajajo štiri beta verige: [http://en.wikipedia.org/wiki/LAMB1 LAMB1], [http://en.wikipedia.org/wiki/LAMB2 LAMB2], [http://en.wikipedia.org/wiki/LAMB3 LAMB3], [http://en.wikipedia.org/wiki/LAMB4 LAMB4]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Obstajajo štiri beta verige: [http://en.wikipedia.org/wiki/LAMB1 LAMB1], [http://en.wikipedia.org/wiki/LAMB2 LAMB2], [http://en.wikipedia.org/wiki/LAMB3 LAMB3], [http://en.wikipedia.org/wiki/LAMB4 LAMB4]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del>* Obstajajo tri gama verige: [http://en.wikipedia.org/wiki/LAMC1 LAMC1], [http://en.wikipedia.org/wiki/LAMC2 LAMC2], [http://en.wikipedia.org/wiki/LAMC3 LAMC3]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Obstajajo tri gama verige: [http://en.wikipedia.org/wiki/LAMC1 LAMC1], [http://en.wikipedia.org/wiki/LAMC2 LAMC2], [http://en.wikipedia.org/wiki/LAMC3 LAMC3]</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== UPORABNOST V RAZISKAVAH ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== UPORABNOST V RAZISKAVAH ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Laminine lahko uporabljamo za gojenje pluripotentnih matičnih celic, ki so problematične za gojenje na drugih podlagah. Uporabljajo <del style="font-weight: bold; text-decoration: none;">se </del>predvsem dve vrsti: laminin-111 in mešanica laminin-511 in laminin-521.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Laminine lahko uporabljamo za gojenje pluripotentnih matičnih celic, ki so problematične za gojenje na drugih podlagah. Uporabljajo predvsem dve vrsti: laminin-111 in mešanica laminin-511 in laminin-521.</div></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== VIRI ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== VIRI ==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[http://en.wikipedia.org/wiki/Laminin wiki/Laminin]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>[http://en.wikipedia.org/wiki/Laminin wiki/Laminin]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>[http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/structural-proteins/laminin.html www.sigmaaldrich.com]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/structural-proteins/laminin.html www.sigmaaldrich.com]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>[http://219.221.200.61/ywwy/zbsw%28E%29/edetail4.htm Noncollagen components of the ECM]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* </ins>[http://macromoleculeinsights.com/laminin.php macromoleculeinsights.com/laminin]</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[http://219.221.200.61/ywwy/zbsw%28E%29/edetail4.htm Noncollagen components of the ECM]</div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[http://macromoleculeinsights.com/laminin.php macromoleculeinsights.com/laminin]</div></td><td colspan="2" class="diff-side-added"></td></tr>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Laminin&diff=4474&oldid=prev
Kranjc.alan at 11:28, 11 December 2010
2010-12-11T11:28:18Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:28, 11 December 2010</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== LAMININ ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Laminin je glavna povezovalna beljakovina v bazalni lamini (Bazalna lamina je tanka mrežasta struktura, ki celice epitela, mišičnega in živčnega tkiva ločuje od vezivnega tkiva, ki jih obdaja), ki veže vse elemente bazalne lamine in tako tvori temeljno omrežje za vezavo večine celic in organov. Laminini so biološko aktivnih del bazalne lamine, ki vplivajo na celične diferenciacije, migracije, oprijema, kot tudi fenotip in preživetje.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Laminin je glavna povezovalna beljakovina v bazalni lamini (Bazalna lamina je tanka mrežasta struktura, ki celice epitela, mišičnega in živčnega tkiva ločuje od vezivnega tkiva, ki jih obdaja), ki veže vse elemente bazalne lamine in tako tvori temeljno omrežje za vezavo večine celic in organov. Laminini so biološko aktivnih del bazalne lamine, ki vplivajo na celične diferenciacije, migracije, oprijema, kot tudi fenotip in preživetje.</div></td></tr>
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Kranjc.alan
https://wiki.fkkt.uni-lj.si/index.php?title=Laminin&diff=4473&oldid=prev
Kranjc.alan at 11:12, 11 December 2010
2010-12-11T11:12:14Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://macromoleculeinsights.com/laminin.php macromoleculeinsights.com/laminin]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[http://macromoleculeinsights.com/laminin.php macromoleculeinsights.com/laminin]</div></td></tr>
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Kranjc.alan
https://wiki.fkkt.uni-lj.si/index.php?title=Laminin&diff=4471&oldid=prev
Kranjc.alan: New page: == LAMININ == Laminin je glavna povezovalna beljakovina v bazalni lamini (Bazalna lamina je tanka mrežasta struktura, ki celice epitela, mišičnega in živčnega tkiva ločuje od vezivn...
2010-12-11T11:08:09Z
<p>New page: == LAMININ == Laminin je glavna povezovalna beljakovina v bazalni lamini (Bazalna lamina je tanka mrežasta struktura, ki celice epitela, mišičnega in živčnega tkiva ločuje od vezivn...</p>
<p><b>New page</b></p><div>== LAMININ ==<br />
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Laminin je glavna povezovalna beljakovina v bazalni lamini (Bazalna lamina je tanka mrežasta struktura, ki celice epitela, mišičnega in živčnega tkiva ločuje od vezivnega tkiva, ki jih obdaja), ki veže vse elemente bazalne lamine in tako tvori temeljno omrežje za vezavo večine celic in organov. Laminini so biološko aktivnih del bazalne lamine, ki vplivajo na celične diferenciacije, migracije, oprijema, kot tudi fenotip in preživetje.<br />
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== ZGRADBA IN FUNKCIJA ==<br />
Lamininska molekula je sestavljena iz treh velikih polipeptidov-α, β1 in β2 (γ) povezanih z disulfidnimi mostički. Lamininske molekule so poimenovane glede na njihovo sestavo verige. Tako laminin-511 vsebuje α5, β1 in γ1 (β2) verigo. Obstaja še štirinajst drugih kombinacij verig. Beljakovina je oblike znaka plus z eno dolgo roko. [http://219.221.200.61/ywwy/zbsw(E)/pic/ech4-6.jpg Slika1]Tri krajše roke se vežejo na druge molekule laminina, daljša roka pa se veže na celice in tako pomaga sidrati tkiva. Povezuje pa se tudi s kolagenom.[http://www.sigmaaldrich.com/etc/medialib/life-science/metabolomics/enzyme-explorer/laminin.Par.0001.Image.484.gif Slika2]<br />
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== VRSTE ==<br />
Laminini so kombinacije različnih alfa-, beta-in gama-verig.<br />
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* Obstaja pet oblik alfa verige: [http://en.wikipedia.org/wiki/LAMA1 LAMA1], [http://en.wikipedia.org/wiki/LAMA2 LAMA2], [http://en.wikipedia.org/wiki/LAMA3 LAMA3], [http://en.wikipedia.org/wiki/LAMA4 LAMA4], [http://en.wikipedia.org/wiki/LAMA5 LAMA5]<br />
* Obstajajo štiri beta verige: [http://en.wikipedia.org/wiki/LAMB1 LAMB1], [http://en.wikipedia.org/wiki/LAMB2 LAMB2], [http://en.wikipedia.org/wiki/LAMB3 LAMB3], [http://en.wikipedia.org/wiki/LAMB4 LAMB4]<br />
* Obstajajo tri gama verige: [http://en.wikipedia.org/wiki/LAMC1 LAMC1], [http://en.wikipedia.org/wiki/LAMC2 LAMC2], [http://en.wikipedia.org/wiki/LAMC3 LAMC3]<br />
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== UPORABNOST V RAZISKAVAH ==<br />
Laminine lahko uporabljamo za gojenje pluripotentnih matičnih celic, ki so problematične za gojenje na drugih podlagah. Uporabljajo se predvsem dve vrsti: laminin-111 in mešanica laminin-511 in laminin-521.<br />
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== VIRI ==<br />
[http://en.wikipedia.org/wiki/Laminin wiki/Laminin]<br />
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[http://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/structural-proteins/laminin.html www.sigmaaldrich.com]<br />
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[http://219.221.200.61/ywwy/zbsw%28E%29/edetail4.htm Noncollagen components of the ECM]<br />
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[http://macromoleculeinsights.com/laminin.php macromoleculeinsights.com/laminin]</div>
Kranjc.alan