https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Nefrin
Nefrin - Revision history
2026-04-06T04:11:44Z
Revision history for this page on the wiki
MediaWiki 1.39.3
https://wiki.fkkt.uni-lj.si/index.php?title=Nefrin&diff=7691&oldid=prev
Mirjam at 15:02, 6 January 2013
2013-01-06T15:02:28Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:02, 6 January 2013</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''<font size=+1 color=red>Nefrin</font>''' je membranska <font size=+1 color=blue>[[beljakovina]]</font> potrebna </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''<font size=+1 color=red>Nefrin</font>''' je membranska <font size=+1 color=blue>[[beljakovina]]</font> potrebna </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>za pravilno delovanje ledvične filtracijske pregrade v <font size=+1 color=blue>[[glomerulu]]</font>, kjer kri vstopa </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>za pravilno delovanje ledvične filtracijske pregrade v <font size=+1 color=blue>[[glomerulu]]</font>, kjer kri vstopa </div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l39">Line 39:</td>
<td colspan="2" class="diff-lineno">Line 37:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>http://diabetes.diabetesjournals.org/content/56/4/1127.full</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>http://diabetes.diabetesjournals.org/content/56/4/1127.full</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:LEX]]</ins></div></td></tr>
</table>
Mirjam
https://wiki.fkkt.uni-lj.si/index.php?title=Nefrin&diff=7635&oldid=prev
Mirjam: /* Nefrin */
2013-01-04T19:58:37Z
<p><span dir="auto"><span class="autocomment">Nefrin</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:58, 4 January 2013</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
<td colspan="2" class="diff-lineno">Line 1:</td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== Nefrin ==</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''<font size=+1 color=red>Nefrin</font>''' je membranska <font size=+1 color=blue>[[beljakovina]]</font> potrebna </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''<font size=+1 color=red>Nefrin</font>''' je membranska <font size=+1 color=blue>[[beljakovina]]</font> potrebna </div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l22">Line 22:</td>
<td colspan="2" class="diff-lineno">Line 22:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Zunanji del molekule je sestavljen iz 8 imunoglobulinskih (Ig-domain) obročev in enega <font size=+1 color=red>[[fibronektin]]</font>-skega šestčlenskega obroča.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Zunanji del molekule je sestavljen iz 8 imunoglobulinskih (Ig-domain) obročev in enega <font size=+1 color=red>[[fibronektin]]</font>-skega šestčlenskega obroča.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Nazven ima obliko zadrge z vmesnimi režami skozi katere prehajajo manjše molekule (voda, sladkor, sol…), ki tvorijo primarni urin.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Nazven ima obliko zadrge z vmesnimi režami skozi katere prehajajo manjše molekule (voda, sladkor, sol…), ki tvorijo primarni urin.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
</table>
Mirjam
https://wiki.fkkt.uni-lj.si/index.php?title=Nefrin&diff=7634&oldid=prev
Mirjam: New page: == Nefrin == '''<font size=+1 color=red>Nefrin</font>''' je membranska <font size=+1 color=blue>beljakovina</font> potrebna za pravilno delovanje ledvične filtracijske pregrade v <f...
2013-01-04T19:57:16Z
<p>New page: == Nefrin == '''<font size=+1 color=red>Nefrin</font>''' je membranska <font size=+1 color=blue><a href="/index.php?title=Beljakovina&action=edit&redlink=1" class="new" title="Beljakovina (page does not exist)">beljakovina</a></font> potrebna za pravilno delovanje ledvične filtracijske pregrade v <f...</p>
<p><b>New page</b></p><div>== Nefrin ==<br />
<br />
'''<font size=+1 color=red>Nefrin</font>''' je membranska <font size=+1 color=blue>[[beljakovina]]</font> potrebna <br />
za pravilno delovanje ledvične filtracijske pregrade v <font size=+1 color=blue>[[glomerulu]]</font>, kjer kri vstopa <br />
v <font size=+1 color=blue>[[nefron]]</font> (osnovna gradbena enota ledvic). Ledvična funkcijska pregrada sestoji iz endotelskih celic glomerula z vmesnimi porami, bazalne membrane glomerula, ''podocitov'' - celic, ki obdajajo kapilare v bowmanovi kapsuli. <br />
<br />
<font size=+1 color=red>Nefrin</font> je transmembranski protein in je strukturna komponenta režne prepone ali <font size=+1 color=blue>[[filtracijska reža]]</font>. Velikim molekulam kot so beljakovine in maščobne kisline preprečuje uhajanje v primarni urin, vendar omogoča prehajanje vode, sladkorjev in soli.<br />
<br />
Mutacija gena za izgradnjo nefrina je povezana s prirojenim <font size=+1 color=blue>nefrotskim sindromom</font>(finskega tipa- <font size=+1 color=green>[[NPHS1]]</font><br/>) ta povzroča, da velike količine beljakovin uhajajo v urin ('''''proteinuria'''''-prisotnost strukturnih beljakovin v urinu).<br />
Nefrin je tudi ključen za delovanje inzulina v glomerulnih celicah (podocitih).<br />
<br />
<br />
[http://en.wikipedia.org/wiki/File:Filtration_barrier.svg] '''<font size=+1 color=blue>Prikaz delovanja filtracijske pregrade glomerulu:</font> '''<br />
<br />
*<font size=+1 color=blue>Sistem filtracijske pregrade, (kri- urin), v ledvicah:</font><br />
*#A.<font size=+1 color=green>endotelijske celice v glomerulih</font><br/>: 1. pora (<font size=+1 color=red>fenestra</font>)<br />
*#B. <font size=+1 color=green>bazalna membrana glomerula</font><br/>: 1. Lamina rara interna 2. Lamina Densa 3. lamina externa rara<br />
*#C.<font size=+1 color=green>podociti</font><br/>: 1. encimski in strukturni proteini 2. filtracijska reža 3. diafragma<br />
<br />
<br />
[http://ars.els-cdn.com/content/image/1-s2.0-S0002944010648298-gr1.jpg]'''<font size=+1 color=green>Molekulska struktura nefrina</font><br/>'''<br />
Zunanji del molekule je sestavljen iz 8 imunoglobulinskih (Ig-domain) obročev in enega <font size=+1 color=red>[[fibronektin]]</font>-skega šestčlenskega obroča.<br />
Nazven ima obliko zadrge z vmesnimi režami skozi katere prehajajo manjše molekule (voda, sladkor, sol…), ki tvorijo primarni urin.<br />
<br />
<br />
== Viri ==<br />
http://en.wikipedia.org/wiki/Nephrin<br />
<br />
http://www.sciencedirect.com/science/article/pii/S0002944010648298<br />
<br />
http://www.pnas.org/content/96/14/7962.abstract<br />
<br />
<br />
== Zunanje povezave ==<br />
http://en.wikipedia.org/wiki/File:Filtration_barrier.svg<br />
<br />
http://www.sciencedirect.com/science/article/pii/S0002944010648298<br />
<br />
http://ars.els-cdn.com/content/image/1-s2.0-S0002944010648298-gr1.jpg<br />
<br />
http://diabetes.diabetesjournals.org/content/56/4/1127.full</div>
Mirjam