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Prostaciklin - Revision history
2026-04-07T10:15:54Z
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MDolinar at 14:09, 4 February 2013
2013-02-04T14:09:08Z
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Prostaciklin==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Prostaciklin==</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2) [http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 <del style="font-weight: bold; text-decoration: none;">Skica </del>molekule] <del style="font-weight: bold; text-decoration: none;"> </del>je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2) [http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 <ins style="font-weight: bold; text-decoration: none;">(skica </ins>molekule<ins style="font-weight: bold; text-decoration: none;">)</ins>] je derivat <ins style="font-weight: bold; text-decoration: none;">[[arahidonska kislina|</ins>arahidonske kisline<ins style="font-weight: bold; text-decoration: none;">]] </ins>in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Arahidonska kislina]] se pod vplivom encima ciklooksigenaze najprej pretvori v PGH2. V žilnih endotelijskih celicah pa iz <del style="font-weight: bold; text-decoration: none;">prostaglandina H2 (</del>PGH2<del style="font-weight: bold; text-decoration: none;">)</del>, pod vplivom encima <del style="font-weight: bold; text-decoration: none;">prostaciklinsintaze </del>[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 <del style="font-weight: bold; text-decoration: none;">Slika </del>encima], nastaja PGI2<del style="font-weight: bold; text-decoration: none;">. </del>[http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png <del style="font-weight: bold; text-decoration: none;">Shema</del>]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Arahidonska kislina]] se pod vplivom encima <ins style="font-weight: bold; text-decoration: none;">[[ciklooksigenaza|</ins>ciklooksigenaze<ins style="font-weight: bold; text-decoration: none;">]] </ins>najprej pretvori v <ins style="font-weight: bold; text-decoration: none;">[[prostaglandini|prostaglandin]] H2 (</ins>PGH2<ins style="font-weight: bold; text-decoration: none;">)</ins>. V žilnih endotelijskih celicah pa iz PGH2, pod vplivom encima <ins style="font-weight: bold; text-decoration: none;">[[prostaciklin sintaza|prostaciklin sintaze]] </ins>[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 <ins style="font-weight: bold; text-decoration: none;">(prostorska zgradba </ins>encima<ins style="font-weight: bold; text-decoration: none;">)</ins>], nastaja <ins style="font-weight: bold; text-decoration: none;">prostagladin I2 (</ins>PGI2<ins style="font-weight: bold; text-decoration: none;">) </ins>[http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png <ins style="font-weight: bold; text-decoration: none;">(shema sinteze)</ins>]<ins style="font-weight: bold; text-decoration: none;">.</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Odkrili so ga leta 1976. Je močan <del style="font-weight: bold; text-decoration: none;">[[</del>vazodilatator<del style="font-weight: bold; text-decoration: none;">]]</del>, ki sodeluje pri relaksaciji mišic in ima antagonistične učinke proti [[tromboksan]]u. Je tudi močen zaviralec agregacije trombocitov (zavira aktivacijo krvnih ploščic).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Odkrili so ga leta 1976. Je močan vazodilatator, ki sodeluje pri relaksaciji mišic in ima antagonistične učinke proti [[tromboksan]]u. Je tudi močen zaviralec agregacije trombocitov (zavira aktivacijo krvnih ploščic).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>PGI2 ima kratek razpolovni čas. Pri <del style="font-weight: bold; text-decoration: none;">37°C </del>in pH 7,4 je razpolovni čas <del style="font-weight: bold; text-decoration: none;">2min</del>, zato deluje blizu mesta sinteze. PGI2 je stabilnejši v bazičnem <del style="font-weight: bold; text-decoration: none;">mediju</del>, še posebej pri pH nad 8,4. Pri <del style="font-weight: bold; text-decoration: none;">22°C </del>po 20 min ni več zaznati njegovega delovanja, saj preide v stabilen produkt [[6-keto PGF1α]].</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>PGI2 ima kratek razpolovni čas. Pri <ins style="font-weight: bold; text-decoration: none;">37 °C </ins>in pH 7,4 je razpolovni čas <ins style="font-weight: bold; text-decoration: none;">2 min.</ins>, zato deluje blizu mesta sinteze. PGI2 je stabilnejši v bazičnem <ins style="font-weight: bold; text-decoration: none;">okolju</ins>, še posebej pri pH nad 8,4. Pri <ins style="font-weight: bold; text-decoration: none;">22 °C </ins>po 20 min<ins style="font-weight: bold; text-decoration: none;">. </ins>ni več zaznati njegovega delovanja, saj preide v stabilen produkt [[6-keto PGF1α]].</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula je <del style="font-weight: bold; text-decoration: none;">C20H32O5</del>.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula je <ins style="font-weight: bold; text-decoration: none;">C<sub>20</sub>H<sub>32</sub>O<sub>5</sub></ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega <del style="font-weight: bold; text-decoration: none;">pritiska </del>v pljučih (bolezen: <del style="font-weight: bold; text-decoration: none;">pulmonary arterial hypertension- </del>pljučna hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega <ins style="font-weight: bold; text-decoration: none;">tlaka </ins>v pljučih (bolezen: pljučna <ins style="font-weight: bold; text-decoration: none;">arterijska </ins>hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
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MDolinar
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7594&oldid=prev
Evatrdin: /* Prostaciklin */
2013-01-01T18:09:49Z
<p><span dir="auto"><span class="autocomment">Prostaciklin</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:09, 1 January 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2) [http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Arahidonska kislina]] se pod vplivom encima ciklooksigenaze najprej pretvori v PGH2. V žilnih endotelijskih celicah pa iz prostaglandina H2 (PGH2), pod vplivom encima prostaciklinsintaze [http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 Slika encima], nastaja PGI2. [http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png Shema]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Arahidonska kislina]] se pod vplivom encima ciklooksigenaze najprej pretvori v PGH2. V žilnih endotelijskih celicah pa iz prostaglandina H2 (PGH2), pod vplivom encima prostaciklinsintaze [http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 Slika encima], nastaja PGI2. [http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png Shema]</div></td></tr>
</table>
Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7593&oldid=prev
Evatrdin: /* Viri */
2013-01-01T18:05:49Z
<p><span dir="auto"><span class="autocomment">Viri</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:05, 1 January 2013</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 Prostacyclinsynthase, Wikimedia commons]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 Prostacyclinsynthase, Wikimedia commons]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Prostaglandin I2, Answers]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Prostaglandin I2, Answers]</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [[Category:LEX]]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Zunanje povezave ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Zunanje povezave ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://arthritis-research.com/content/10/5/R120/figure/F8?highres=y Arthritis Research & Therapy 2008]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://arthritis-research.com/content/10/5/R120/figure/F8?highres=y Arthritis Research & Therapy 2008]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://bloodjournal.hematologylibrary.org/content/53/2/244.full.pdf Blood journal]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>*[http://bloodjournal.hematologylibrary.org/content/53/2/244.full.pdf Blood journal]</div></td></tr>
</table>
Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7592&oldid=prev
Evatrdin: /* Category:Prostaciklin */
2013-01-01T18:05:21Z
<p><span dir="auto"><span class="autocomment">Category:Prostaciklin</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:05, 1 January 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==<del style="font-weight: bold; text-decoration: none;">[[Category:</del>Prostaciklin<del style="font-weight: bold; text-decoration: none;">]]</del>==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>==Prostaciklin==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
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Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7591&oldid=prev
Evatrdin: /* Category:LEX Prostaciklin */
2013-01-01T18:03:40Z
<p><span dir="auto"><span class="autocomment">Category:LEX Prostaciklin</span></span></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:03, 1 January 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>==[[Category:<del style="font-weight: bold; text-decoration: none;">LEX </del>Prostaciklin]]==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>==[[Category:Prostaciklin]]==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
</table>
Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7590&oldid=prev
Evatrdin: /* [ [ Category:LEX Prostaciklin ] ] */
2013-01-01T18:02:51Z
<p><span dir="auto"><span class="autocomment">[ [ Category:LEX Prostaciklin ] ]</span></span></p>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== <del style="font-weight: bold; text-decoration: none;"> </del>[ [ Category:LEX Prostaciklin ] ]==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>==[[Category:LEX Prostaciklin]]==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
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Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7589&oldid=prev
Evatrdin: /* Prostaciklin */
2013-01-01T18:01:35Z
<p><span dir="auto"><span class="autocomment">Prostaciklin</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:01, 1 January 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>== Prostaciklin==</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>== <ins style="font-weight: bold; text-decoration: none;"> [ [ Category:LEX </ins>Prostaciklin <ins style="font-weight: bold; text-decoration: none;">] ]</ins>==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>'''Prostaciklin''' ali''' prostaglandin I2''' (PGI2)[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
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Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7588&oldid=prev
Evatrdin: /* Prostaciklin */
2013-01-01T17:59:57Z
<p><span dir="auto"><span class="autocomment">Prostaciklin</span></span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:59, 1 January 2013</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega pritiska v pljučih (bolezen: pulmonary arterial hypertension- pljučna hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega pritiska v pljučih (bolezen: pulmonary arterial hypertension- pljučna hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== Viri ==</div></td></tr>
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Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7587&oldid=prev
Evatrdin at 17:59, 1 January 2013
2013-01-01T17:59:19Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:59, 1 January 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''<del style="font-weight: bold; text-decoration: none;">PROSTACIKLIN</del>''' ali '''prostaglandin I2''' (PGI2) je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Prostaciklin==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''<ins style="font-weight: bold; text-decoration: none;">Prostaciklin</ins>''' ali''' prostaglandin I2''' (PGI2)<ins style="font-weight: bold; text-decoration: none;">[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Skica molekule] </ins> je derivat arahidonske kisline in spada med [[eikozanoid]]e (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>[[Arahidonska kislina]] se pod vplivom encima ciklooksigenaze najprej pretvori v PGH2. V žilnih endotelijskih celicah pa iz prostaglandina H2 (PGH2), pod vplivom encima prostaciklinsintaze, nastaja PGI2. [http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png Shema]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>[[Arahidonska kislina]] se pod vplivom encima ciklooksigenaze najprej pretvori v PGH2. V žilnih endotelijskih celicah pa iz prostaglandina H2 (PGH2), pod vplivom encima prostaciklinsintaze <ins style="font-weight: bold; text-decoration: none;">[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 Slika encima]</ins>, nastaja PGI2. [http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png Shema]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Odkrili so ga leta 1976. Je močan [[vazodilatator]], ki sodeluje pri relaksaciji mišic in ima antagonistične učinke proti [[tromboksan]]u. Je tudi močen zaviralec agregacije trombocitov (zavira aktivacijo krvnih ploščic).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Odkrili so ga leta 1976. Je močan [[vazodilatator]], ki sodeluje pri relaksaciji mišic in ima antagonistične učinke proti [[tromboksan]]u. Je tudi močen zaviralec agregacije trombocitov (zavira aktivacijo krvnih ploščic).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>PGI2 ima kratek razpolovni čas. Pri 37°C in pH 7,4 je razpolovni čas 2min, zato deluje blizu mesta sinteze. PGI2 je stabilnejši v bazičnem mediju, še posebej pri pH nad 8,4. Pri 22°C po 20 min ni več zaznati njegovega delovanja, saj preide v stabilen produkt 6-keto PGF1α.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>PGI2 ima kratek razpolovni čas. Pri 37°C in pH 7,4 je razpolovni čas 2min, zato deluje blizu mesta sinteze. PGI2 je stabilnejši v bazičnem mediju, še posebej pri pH nad 8,4. Pri 22°C po 20 min ni več zaznati njegovega delovanja, saj preide v stabilen produkt <ins style="font-weight: bold; text-decoration: none;">[[</ins>6-keto PGF1α<ins style="font-weight: bold; text-decoration: none;">]]</ins>.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula je C20H32O5.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula je C20H32O5.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega pritiska v pljučih (bolezen: pulmonary arterial hypertension- pljučna hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega pritiska v pljučih (bolezen: pulmonary arterial hypertension- pljučna hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Viri ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">* [http://www.ffa.uni-lj.si/fileadmin/datoteke/Knjiznica/diplome/2008/Oman_Luka_dipl_nal_2008.pdf OMAN, L. Diplomska naloga: Vpliv vnetnih dejavnikov na izražanje 6-keto prostaglandina F1 alfa v humanih endotelijskih celicah. Ljubljana, 2008]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://www.mayoclinic.com/health/drug-information/DR600625 Epoprostenol, Mayoclinic]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://www.medicinenet.com/epoprostenol-inj/article.htm Epoprostenol, Medicinenet]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://lsm1.amebis.si/lsmeds/novPogoj.aspx?pPogoj=prostaciklin; Slovenski medicinski e-slovar, Univerza v Ljubljani, Medicinska fakulteta]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://en.wikipedia.org/wiki/Prostacyclin Prostacyclin, Wikipedia]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*TIŠLER, M.: Narava, človek in kemija. Ljubljana: Državna založba Slovenije, 1985.stran 58-62</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*REŽEN, T. Predavanje iz biokemije I. Univerza v Ljubljani, Medicinska fakulteta. Ljubljana, 2012</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png, Thromboxane synthesis, Wikipedia]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=hDbZ8j8LBL9ncM:&imgrefurl=http://commons.wikipedia.org/wiki/File:Prostacyclin%2520synthase%25202IAG.png&docid=RO_Rr7cWXUF-FM&imgurl=http://upload.wikimedia.org/wikipedia/commons/6/69/Prostacyclin_synthase_2IAG.png&w=1200&h=1019&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=819&vpy=284&dur=339&hovh=200&hovw=236&tx=71&ty=89&sig=108518581896734547971&page=1&tbnh=137&tbnw=161&start=0&ndsp=27&ved=1t:429,r:12,s:0,i:120 Prostacyclinsynthase, Wikimedia commons]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://www.google.si/imgres?um=1&hl=sl&sa=N&tbo=d&biw=1280&bih=685&tbm=isch&tbnid=1bALJdBAYZpuTM:&imgrefurl=http://www.answers.com/topic/prostacyclin&docid=UHg-exQAxAy_DM&imgurl=http://content.answcdn.com/main/content/img/oxford/oxfordBiochemistry/0198529171.prostacyclin.1.jpg&w=522&h=342&ei=VSDjUI_FN4iB4gSh54F4&zoom=1&iact=hc&vpx=426&vpy=86&dur=169&hovh=182&hovw=277&tx=121&ty=92&sig=108518581896734547971&page=1&tbnh=137&tbnw=209&start=0&ndsp=27&ved=1t:429,r:10,s:0,i:114 Prostaglandin I2, Answers]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Zunanje povezave ==</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://arthritis-research.com/content/10/5/R120/figure/F8?highres=y Arthritis Research & Therapy 2008]</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">*[http://bloodjournal.hematologylibrary.org/content/53/2/244.full.pdf Blood journal]</ins></div></td></tr>
</table>
Evatrdin
https://wiki.fkkt.uni-lj.si/index.php?title=Prostaciklin&diff=7586&oldid=prev
Evatrdin at 17:15, 1 January 2013
2013-01-01T17:15:00Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:15, 1 January 2013</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>'''PROSTACIKLIN''' ali '''prostaglandin I2''' (PGI2) je derivat <del style="font-weight: bold; text-decoration: none;">[[</del>arahidonske kisline<del style="font-weight: bold; text-decoration: none;">]] </del>in spada med [[<del style="font-weight: bold; text-decoration: none;">eikozanoide</del>]] (lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>'''PROSTACIKLIN''' ali '''prostaglandin I2''' (PGI2) je derivat arahidonske kisline in spada med [[<ins style="font-weight: bold; text-decoration: none;">eikozanoid</ins>]]<ins style="font-weight: bold; text-decoration: none;">e </ins>(lipide). To so pomožni hormoni, ki delujejo na mestu nastanka.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Iz arahidonske kisline </del>pod vplivom encima ciklooksigenaze najprej <del style="font-weight: bold; text-decoration: none;">nastane </del>PGH2. V žilnih endotelijskih celicah pa iz prostaglandina H2 (PGH2), pod vplivom encima prostaciklinsintaze, nastaja PGI2. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Arahidonska kislina]] se </ins>pod vplivom encima ciklooksigenaze najprej <ins style="font-weight: bold; text-decoration: none;">pretvori v </ins>PGH2. V žilnih endotelijskih celicah pa iz prostaglandina H2 (PGH2), pod vplivom encima prostaciklinsintaze, nastaja PGI2. <ins style="font-weight: bold; text-decoration: none;">[http://sl.wikipedia.org/wiki/Slika:Thromboxane_synthesis.png Shema]</ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Odkrili so ga leta 1976. Je močan [[vazodilatator]] , ki sodeluje pri relaksaciji mišic in ima antagonistične učinke proti [[tromboksan]]u. Je tudi močen zaviralec agregacije trombocitov (zavira aktivacijo krvnih ploščic).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Odkrili so ga leta 1976. Je močan [[vazodilatator]], ki sodeluje pri relaksaciji mišic in ima antagonistične učinke proti [[tromboksan]]u. Je tudi močen zaviralec agregacije trombocitov (zavira aktivacijo krvnih ploščic).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>PGI2 ima kratek razpolovni čas. Pri 37°C in pH 7,4 je razpolovni čas 2min, zato deluje blizu mesta sinteze. PGI2 je stabilnejši v bazičnem mediju, še posebej pri pH nad 8,4. Pri 22°C po 20 min ni več zaznati njegovega delovanja, saj preide v stabilen produkt 6-keto PGF1α. </div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>PGI2 ima kratek razpolovni čas. Pri 37°C in pH 7,4 je razpolovni čas 2min, zato deluje blizu mesta sinteze. PGI2 je stabilnejši v bazičnem mediju, še posebej pri pH nad 8,4. Pri 22°C po 20 min ni več zaznati njegovega delovanja, saj preide v stabilen produkt 6-keto PGF1α.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula je C20H32O5.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Molekulska formula je C20H32O5.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega pritiska v pljučih (bolezen: pulmonary arterial hypertension- pljučna hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Kot zdravilna učinkovina je prostaciklin znan pod imenom epoprostenol. Kot vazodilatator razširi in sprosti žile v pljučih in drugih delih telesa, s tem pa omogoči lažji pretok krvi po telesu. Uporablja se za zdravljenje visokega krvnega pritiska v pljučih (bolezen: pulmonary arterial hypertension- pljučna hipertenzija) in olajša simptome kot so težko dihanje in utrujenost. Poveča tudi zmožnost gibanja.</div></td></tr>
</table>
Evatrdin