https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Tromboksan Tromboksan - Revision history 2026-04-17T01:24:40Z Revision history for this page on the wiki MediaWiki 1.39.3 https://wiki.fkkt.uni-lj.si/index.php?title=Tromboksan&diff=7836&oldid=prev MDolinar at 11:41, 4 February 2013 2013-02-04T11:41:00Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 11:41, 4 February 2013</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&#039;&#039;&#039;Tromboksan&#039;&#039;&#039; je fiziološko aktivna lipidna molekula v človeškem telesu.Natančneje ga uvrščamo v skupino eikonazoidov,</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&#039;&#039;&#039;Tromboksan&#039;&#039;&#039; je fiziološko aktivna lipidna molekula v človeškem telesu. Natančneje ga uvrščamo v skupino eikonazoidov, ki so derivati <ins style="font-weight: bold; text-decoration: none;">[[arahidonska kislina|</ins>arahidonske kisline<ins style="font-weight: bold; text-decoration: none;">]]</ins>. Njegova biološka vloga je pomembna zlasti pri ranah oziroma poškodovanih tkivih. Ime je dobil po krvnih celicah <ins style="font-weight: bold; text-decoration: none;">trombocitih</ins>, iz katerih so ga prvič izolirali. Tromboksane ločimo na <ins style="font-weight: bold; text-decoration: none;">[[</ins>tromboksan A2<ins style="font-weight: bold; text-decoration: none;">]] </ins>in <ins style="font-weight: bold; text-decoration: none;">[[</ins>tromboksan B2<ins style="font-weight: bold; text-decoration: none;">]]</ins>, ki je njegov metabolit in ni biološko aktiven.</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>ki so derivati arahidonske kisline. Njegova biološka vloga je pomembna zlasti pri ranah oziroma poškodovanih tkivih. Ime je</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>dobil po krvnih celicah <del style="font-weight: bold; text-decoration: none;">trombocitah</del>, iz katerih so ga prvič izolirali. Tromboksane ločimo na tromboksan A2 in tromboksan B2, ki je njegov metabolit in ni biološko aktiven.</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Kemijske lastnosti==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Kemijske lastnosti==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Za tromboksan je značilen šestčlenski obroč,ki vsebuje atom kisika. <del style="font-weight: bold; text-decoration: none;">Njegova </del>molekulska formula <del style="font-weight: bold; text-decoration: none;">je </del>C&lt;sub&gt;20&lt;/sub&gt;H&lt;sub&gt;32&lt;/sub&gt;O&lt;sub&gt;5&lt;/sub&gt;<del style="font-weight: bold; text-decoration: none;">.</del></div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Za tromboksan je značilen šestčlenski obroč, ki vsebuje atom kisika. <ins style="font-weight: bold; text-decoration: none;">Na primer za tromboksan B2 je </ins>molekulska formula C&lt;sub&gt;20&lt;/sub&gt;H&lt;sub&gt;32&lt;/sub&gt;O&lt;sub&gt;5&lt;/sub&gt; <ins style="font-weight: bold; text-decoration: none;">in molska </ins>masa 352,47 g/mol.</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Molska </del>masa <del style="font-weight: bold; text-decoration: none;">je </del>352,47 g/mol.</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Sinteza==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Sinteza==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Nastane kot derivat arahidonske kisline z delovanje ciklooksigenaze, ki tvori prostaglandin H2 , ki je prekurzor v sintezi.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Nastane kot derivat arahidonske kisline z delovanje <ins style="font-weight: bold; text-decoration: none;">[[ciklooksigenaza|</ins>ciklooksigenaze<ins style="font-weight: bold; text-decoration: none;">]]</ins>, ki tvori <ins style="font-weight: bold; text-decoration: none;">[[</ins>prostaglandin H2<ins style="font-weight: bold; text-decoration: none;">]]</ins>, ki je prekurzor v sintezi. Tromboksan A2-sintaza, ki se nahaja v trombocitih, katalizira nastanek tromboksana A2 iz <ins style="font-weight: bold; text-decoration: none;">prostaglandina </ins>H2. Sintezo je mogoče inhibirati<ins style="font-weight: bold; text-decoration: none;">; </ins>najbolj znan zaviralec je <ins style="font-weight: bold; text-decoration: none;">[[</ins>aspirin<ins style="font-weight: bold; text-decoration: none;">]]</ins>, ki zavira ciklooksigenazo in tako prepreči,da bi iz arahidonske kisline nastal</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Tromboksan A2-sintaza,ki se nahaja v trombocitih, katalizira nastanek tromboksana A2 iz <del style="font-weight: bold; text-decoration: none;">prostoglandina </del>H2.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>prekurzor <ins style="font-weight: bold; text-decoration: none;">tromboksana A2, </ins>prostoglandin H2. <ins style="font-weight: bold; text-decoration: none;">Vsakodnevni </ins>odmerki aspirina zmanjšujejo verjetnost srčnega infarkta.</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Sintezo je mogoče inhibirati<del style="font-weight: bold; text-decoration: none;">, </del>najbolj znan zaviralec je aspirin, ki zavira ciklooksigenazo in tako prepreči,da bi iz arahidonske kisline nastal</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>prekurzor prostoglandin H2 <del style="font-weight: bold; text-decoration: none;">za tromboksan A2</del>. <del style="font-weight: bold; text-decoration: none;">Dnevni </del>odmerki aspirina zmanjšujejo verjetnost srčnega infarkta.</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Biološka funkcija==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Biološka funkcija==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Njegova najpomembnejša biološka funkcija je tvorjenje krvnih strdkov.To doseže s tem , da se <del style="font-weight: bold; text-decoration: none;">ve </del>na posebne receptorje na celični membrani <del style="font-weight: bold; text-decoration: none;">z imenom G protein G&lt;sub&gt;q&lt;/sub&gt;</del>, kjer z vezavo izzove sintezo glikoproteina IIb/IIIa ,ki se nahaja v celični membrani in se je sposoben vezati na fibrinogen v krvi in tako tvoriti krvne strdke. Hkrati aktivira v drugih trombocitih sintezo tromboksana A2.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Njegova najpomembnejša biološka funkcija je tvorjenje krvnih strdkov. To doseže s tem, da se <ins style="font-weight: bold; text-decoration: none;">veže </ins>na posebne receptorje na celični membrani, kjer z vezavo izzove sintezo glikoproteina IIb/IIIa ,ki se nahaja v celični membrani in se je sposoben vezati na fibrinogen v krvi in tako tvoriti krvne strdke. Hkrati aktivira v drugih trombocitih sintezo tromboksana A2.</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Slikovno gradivo==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Slikovno gradivo==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">*Slike</del>:</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">Slika</ins>: Tromboksan A2 [http://upload.wikimedia.org/wikipedia/commons/f/f5/Thromboxane_A2.png]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del>Tromboksan A2 [http://upload.wikimedia.org/wikipedia/commons/f/f5/Thromboxane_A2.png]</div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Viri==</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.lek.si/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* [http://en.wikipedia.org/wiki/Thromboxane<del style="font-weight: bold; text-decoration: none;">, </del>Wikipedia]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* [http://en.wikipedia.org/wiki/Thromboxane Wikipedia]</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* Temelji biokemije:Rodney Boyer<del style="font-weight: bold; text-decoration: none;">-</del>Ljubljana<del style="font-weight: bold; text-decoration: none;">,</del>Študentska založba 2005, stran 222-223</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* Temelji biokemije:Rodney Boyer<ins style="font-weight: bold; text-decoration: none;">. </ins>Ljubljana<ins style="font-weight: bold; text-decoration: none;">: </ins>Študentska založba 2005, stran 222-223</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Zunanje povezave==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>==Zunanje povezave==</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83335<del style="font-weight: bold; text-decoration: none;">, </del>Mayo <del style="font-weight: bold; text-decoration: none;">clinic</del>]</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>* [http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83335 Mayo <ins style="font-weight: bold; text-decoration: none;">Clinic</ins>]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:LEX]]</div></td></tr> </table> MDolinar https://wiki.fkkt.uni-lj.si/index.php?title=Tromboksan&diff=7578&oldid=prev Rmarko: New page: '''Tromboksan''' je fiziološko aktivna lipidna molekula v človeškem telesu.Natančneje ga uvrščamo v skupino eikonazoidov, ki so derivati arahidonske kisline. Njegova biološka vloga ... 2012-12-31T04:03:21Z <p>New page: &#039;&#039;&#039;Tromboksan&#039;&#039;&#039; je fiziološko aktivna lipidna molekula v človeškem telesu.Natančneje ga uvrščamo v skupino eikonazoidov, ki so derivati arahidonske kisline. Njegova biološka vloga ...</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Tromboksan&#039;&#039;&#039; je fiziološko aktivna lipidna molekula v človeškem telesu.Natančneje ga uvrščamo v skupino eikonazoidov,<br /> ki so derivati arahidonske kisline. Njegova biološka vloga je pomembna zlasti pri ranah oziroma poškodovanih tkivih. Ime je<br /> dobil po krvnih celicah trombocitah, iz katerih so ga prvič izolirali. Tromboksane ločimo na tromboksan A2 in tromboksan B2, ki je njegov metabolit in ni biološko aktiven.<br /> <br /> ==Kemijske lastnosti==<br /> Za tromboksan je značilen šestčlenski obroč,ki vsebuje atom kisika. Njegova molekulska formula je C&lt;sub&gt;20&lt;/sub&gt;H&lt;sub&gt;32&lt;/sub&gt;O&lt;sub&gt;5&lt;/sub&gt;.<br /> Molska masa je 352,47 g/mol.<br /> <br /> ==Sinteza==<br /> Nastane kot derivat arahidonske kisline z delovanje ciklooksigenaze, ki tvori prostaglandin H2 , ki je prekurzor v sintezi.<br /> Tromboksan A2-sintaza,ki se nahaja v trombocitih, katalizira nastanek tromboksana A2 iz prostoglandina H2.<br /> Sintezo je mogoče inhibirati, najbolj znan zaviralec je aspirin, ki zavira ciklooksigenazo in tako prepreči,da bi iz arahidonske kisline nastal<br /> prekurzor prostoglandin H2 za tromboksan A2. Dnevni odmerki aspirina zmanjšujejo verjetnost srčnega infarkta.<br /> <br /> ==Biološka funkcija==<br /> Njegova najpomembnejša biološka funkcija je tvorjenje krvnih strdkov.To doseže s tem , da se ve na posebne receptorje na celični membrani z imenom G protein G&lt;sub&gt;q&lt;/sub&gt;, kjer z vezavo izzove sintezo glikoproteina IIb/IIIa ,ki se nahaja v celični membrani in se je sposoben vezati na fibrinogen v krvi in tako tvoriti krvne strdke. Hkrati aktivira v drugih trombocitih sintezo tromboksana A2.<br /> <br /> <br /> ==Slikovno gradivo==<br /> *Slike:<br /> Tromboksan A2 [http://upload.wikimedia.org/wikipedia/commons/f/f5/Thromboxane_A2.png]<br /> <br /> ==Viri==<br /> * [http://www.lek.si/medicinski-slovar/ Slovenski medicinski e-slovar; Univerza v Ljubljani, Medicinska fakulteta, Lek d. d.]<br /> * [http://en.wikipedia.org/wiki/Thromboxane, Wikipedia]<br /> * Temelji biokemije:Rodney Boyer-Ljubljana,Študentska založba 2005, stran 222-223<br /> <br /> ==Zunanje povezave==<br /> * [http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83335, Mayo clinic]<br /> <br /> [[Category:LEX]]</div> Rmarko