https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=User_talk%3AUrsaK 2026-04-04T16:07:03Z Revision history for this page on the wiki MediaWiki 1.39.3 https://wiki.fkkt.uni-lj.si/index.php?title=User_talk:UrsaK&diff=8709&oldid=prev 2014-01-04T18:32:22Z

<p>Removing all content from page</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:32, 4 January 2014</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td> <td colspan="2" class="diff-lineno">Line 1:</td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== '''Ubikvitin ligaza''' ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Ubikvitin ligaza je '''multiencimski kompleks''', ki sodeluje pri ubikvitinaciji, kar pomeni, da na delno denaturiran ali okvarjen protein, ki ima razkrito specifično mesto (da ga lahko ubikvitin ligaza prepozna) veže majhen protein, imenovan ubikvitin ter ga tako označi za znotrajcelično razgradnjo v proteasomu (proteolitični kompleks). Za ta proces je potrebna energija v obliki ATP. Celice vsebujejo okoli 300 različnih tipov encimov ubikvitin ligaz, zato pravimo, da je njegovo delovanje substratno specifično. Velja pravilo N-konca: encim je specifičen za N-konec.</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">'''2 družini ubikvitin ligaz:'''</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">- RING (Really Interesting New Game), omogoča direkten prenos ubikvitina na substrat</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> </del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">- HECT domena, služi kot intermediat za prenos ubikvitina</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Vezava ubikvitina  poteka v treh korakih, ubikvitin ligaza pa nastopa predvsem v zadnjem delu, ko se na ubikvitin veže ubivitin konjugirajoč encim. Ubikvitin ligaza obenem tudi olajša in pospeši  prenos ubikvitina iz ubikvitin konjugirajočega encima na substrat. Vzpostavi se izopeptidna (kovalentna) vez med ubikvitinom (C-terminalskim delom) in amino skupino na lizinskem ostanku tarčnega proteina.</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Viri:</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://sl.wikipedia.org/wiki/Ubikvitin]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://ibk.mf.uni-lj.si/teaching/objave/Zpredavanje4.pdf]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://bio.ijs.si/brigita/faculty/pdf/encimatika/P11%20Pretvorba%20encimov.pdf]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://www.termania.net/slovarji/slovenski-medicinski-slovar/5542800/ubikvitin-ligaza?query=ubikvitin%20ligaza]</del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Temelji biokemije; Rodney Boyer</del></div></td><td colspan="2" class="diff-side-added"></td></tr> </table>

UrsaK https://wiki.fkkt.uni-lj.si/index.php?title=User_talk:UrsaK&diff=8707&oldid=prev 2014-01-04T18:27:43Z

<p>New page: == &#039;&#039;&#039;Ubikvitin ligaza&#039;&#039;&#039; == Ubikvitin ligaza je &#039;&#039;&#039;multiencimski kompleks&#039;&#039;&#039;, ki sodeluje pri ubikvitinaciji, kar pomeni, da na delno denaturiran ali okvarjen protein, ki ima razkrito s...</p> <p><b>New page</b></p><div>== &#039;&#039;&#039;Ubikvitin ligaza&#039;&#039;&#039; ==<br /> <br /> <br /> Ubikvitin ligaza je &#039;&#039;&#039;multiencimski kompleks&#039;&#039;&#039;, ki sodeluje pri ubikvitinaciji, kar pomeni, da na delno denaturiran ali okvarjen protein, ki ima razkrito specifično mesto (da ga lahko ubikvitin ligaza prepozna) veže majhen protein, imenovan ubikvitin ter ga tako označi za znotrajcelično razgradnjo v proteasomu (proteolitični kompleks). Za ta proces je potrebna energija v obliki ATP. Celice vsebujejo okoli 300 različnih tipov encimov ubikvitin ligaz, zato pravimo, da je njegovo delovanje substratno specifično. Velja pravilo N-konca: encim je specifičen za N-konec.<br /> <br /> &#039;&#039;&#039;2 družini ubikvitin ligaz:&#039;&#039;&#039;<br /> <br /> - RING (Really Interesting New Game), omogoča direkten prenos ubikvitina na substrat<br /> <br /> - HECT domena, služi kot intermediat za prenos ubikvitina<br /> <br /> Vezava ubikvitina poteka v treh korakih, ubikvitin ligaza pa nastopa predvsem v zadnjem delu, ko se na ubikvitin veže ubivitin konjugirajoč encim. Ubikvitin ligaza obenem tudi olajša in pospeši prenos ubikvitina iz ubikvitin konjugirajočega encima na substrat. Vzpostavi se izopeptidna (kovalentna) vez med ubikvitinom (C-terminalskim delom) in amino skupino na lizinskem ostanku tarčnega proteina.<br /> <br /> Viri:<br /> [http://sl.wikipedia.org/wiki/Ubikvitin]<br /> [http://ibk.mf.uni-lj.si/teaching/objave/Zpredavanje4.pdf]<br /> [http://bio.ijs.si/brigita/faculty/pdf/encimatika/P11%20Pretvorba%20encimov.pdf]<br /> [http://www.termania.net/slovarji/slovenski-medicinski-slovar/5542800/ubikvitin-ligaza?query=ubikvitin%20ligaza]<br /> <br /> Temelji biokemije; Rodney Boyer</div>

UrsaK