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Wiki FKKT talk:Community Portal - Revision history
2026-04-15T14:09:10Z
Revision history for this page on the wiki
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WikiSysop: Removing all content from page
2012-11-27T10:07:40Z
<p>Removing all content from page</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 10:07, 27 November 2012</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Selenoproteini vsebujejo enega ali več ostankov aminokisline [[selenocistein]], ki je analog [[cisteina]]. Atom [[žvepla]] v modificirani tiolni skupini v cisteinu je nadomeščen z [[atomom]] [[selena]] v selenocisteinu. Selenocistein je označen kot enaindvajseta [[aminokislina]].</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Image:IrfanView JPG File (.jpg)]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== '''Funkcije selenoproteinov''' ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Večina selenoproteinov katalizira [[oksidacije]] ali [[redukcije]], modificirana tiolna skupina, ki namesto žvepla vsebuje selen, iz selenoproteina vezana v [[aktivno mesto]] [[encima]] sodeluje pri [[reakciji]]. Prednost selena vezanega na [[molekulo]] cisteina pred tiolno skupino oziroma žveplom,je v tem, da ta poveča encimom [[kinetično energijo]]. Prisotnost selena v selenocisteinu je pomembna, ker le ta sodeluje v vsakem od štirih katalitičnih načinov tvorbe encima [[glutaninperoksidaze]].</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">V nekaterih bioloških sistemih imajo selenoproteini strukturno vlogo, ker imajo možnost dioligomerizirati [[proteine]], tako, da formirajo diselenide ali disulfid-selenidne mostičke.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== '''Sinteza selenoproteinov''' ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Biosinteza selenoproteinov je zelo specifična in se razlikuje od [[sinteze]] ostalih proteinov, ker se selenoprotein inkorporira kotranslacijsko in ne posttranslacijsko.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Vstavljanje selenocisteina je koordinirano z [[DNA]] in zahteva analogno funkcijo [[tRNA]] in specifičen [[elongacijski faktor]]( elongacijski faktor SelB), ki se razlikuje od [[elongacijskega faktorja TU]].</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">----</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== '''Vrste selenoproteinov''' ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Pri [[sesalcih]] najdemo oziroma je bilo do sedaj odkritih 30 različnih selenoproteinov, najbolj raziskani pa so: [[Link title]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><h3>Glutaninperoksidaza</h3> je encim sestavljen iz štirih identičnih podenot, pri čemer vsaka vsebuje en selenocistein v aktivnem mestu. Delovanje encima ni še dobro raziskano, vendar domnevajo, da bi lahko deloval le ta [[in vivo]], tako da odstranjuje [[peroksid]] iz [[celice]]in tako preprečuje peroksidacijo [[membran]] in oksidativne poškdbe</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><h3>Selenoprotein P</h3></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Selenoprotein P je protein, ki je bil ekstrahiran iz podganje in človeške [[plazme]] in je povezan oziroma ga povezujejo z endotelijskimi celicami. Njegova vloga še ni znana,naj bi pa imel zunajcelično oksidacijsko-obrambno vlogo.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">Selenoprotein W je protein, ki je bil najden v mišicah in drugih tkivih, njegova vloga še ni najbolj raziskana.</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><h3>Tioredoksin reduktaza</h3> Tioredoksin reduktaza je [[flavoencim]] odvisen od [[NADPH]]. Ta encim reducira [[disulfide]] na [[tioredoksinu]].</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">----</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">== '''Viri''' ==</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><h3>Literatura</h3></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">J. Lennarz, William, Lane, M. Daniel. Encyclopedia of Biological Chemistry (S-Z, volume 4). Elsevier Academic Press. 2004, first edition, ISBN: 978-0-12-443710-4</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"><h3>Zunanje povezave</h3></del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://www.ncbi.nlm.nih.gov/pubmed/11839807]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://www.springer.com/biomed/cancer/book/978-0-387-33826-2]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[http://www.elsevier.com/wps/find/bookdescription.cws_home/703167/description#description]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[[Category:LEX]]</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
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WikiSysop
https://wiki.fkkt.uni-lj.si/index.php?title=Wiki_FKKT_talk:Community_Portal&diff=4642&oldid=prev
Martin Gramc: Selenoproteini
2010-12-11T21:16:35Z
<p>Selenoproteini</p>
<p><b>New page</b></p><div>Selenoproteini vsebujejo enega ali več ostankov aminokisline [[selenocistein]], ki je analog [[cisteina]]. Atom [[žvepla]] v modificirani tiolni skupini v cisteinu je nadomeščen z [[atomom]] [[selena]] v selenocisteinu. Selenocistein je označen kot enaindvajseta [[aminokislina]].<br />
[[Image:IrfanView JPG File (.jpg)]]<br />
----<br />
<br />
== '''Funkcije selenoproteinov''' ==<br />
<br />
Večina selenoproteinov katalizira [[oksidacije]] ali [[redukcije]], modificirana tiolna skupina, ki namesto žvepla vsebuje selen, iz selenoproteina vezana v [[aktivno mesto]] [[encima]] sodeluje pri [[reakciji]]. Prednost selena vezanega na [[molekulo]] cisteina pred tiolno skupino oziroma žveplom,je v tem, da ta poveča encimom [[kinetično energijo]]. Prisotnost selena v selenocisteinu je pomembna, ker le ta sodeluje v vsakem od štirih katalitičnih načinov tvorbe encima [[glutaninperoksidaze]].<br />
V nekaterih bioloških sistemih imajo selenoproteini strukturno vlogo, ker imajo možnost dioligomerizirati [[proteine]], tako, da formirajo diselenide ali disulfid-selenidne mostičke.<br />
<br />
----<br />
<br />
== '''Sinteza selenoproteinov''' ==<br />
<br />
Biosinteza selenoproteinov je zelo specifična in se razlikuje od [[sinteze]] ostalih proteinov, ker se selenoprotein inkorporira kotranslacijsko in ne posttranslacijsko.<br />
Vstavljanje selenocisteina je koordinirano z [[DNA]] in zahteva analogno funkcijo [[tRNA]] in specifičen [[elongacijski faktor]]( elongacijski faktor SelB), ki se razlikuje od [[elongacijskega faktorja TU]].<br />
<br />
----<br />
<br />
== '''Vrste selenoproteinov''' ==<br />
<br />
Pri [[sesalcih]] najdemo oziroma je bilo do sedaj odkritih 30 različnih selenoproteinov, najbolj raziskani pa so: [[Link title]]<br />
<h3>Glutaninperoksidaza</h3> je encim sestavljen iz štirih identičnih podenot, pri čemer vsaka vsebuje en selenocistein v aktivnem mestu. Delovanje encima ni še dobro raziskano, vendar domnevajo, da bi lahko deloval le ta [[in vivo]], tako da odstranjuje [[peroksid]] iz [[celice]]in tako preprečuje peroksidacijo [[membran]] in oksidativne poškdbe<br />
<h3>Selenoprotein P</h3><br />
Selenoprotein P je protein, ki je bil ekstrahiran iz podganje in človeške [[plazme]] in je povezan oziroma ga povezujejo z endotelijskimi celicami. Njegova vloga še ni znana,naj bi pa imel zunajcelično oksidacijsko-obrambno vlogo.<br />
Selenoprotein W je protein, ki je bil najden v mišicah in drugih tkivih, njegova vloga še ni najbolj raziskana.<br />
<h3>Tioredoksin reduktaza</h3> Tioredoksin reduktaza je [[flavoencim]] odvisen od [[NADPH]]. Ta encim reducira [[disulfide]] na [[tioredoksinu]].<br />
<br />
----<br />
<br />
== '''Viri''' ==<br />
<h3>Literatura</h3><br />
J. Lennarz, William, Lane, M. Daniel. Encyclopedia of Biological Chemistry (S-Z, volume 4). Elsevier Academic Press. 2004, first edition, ISBN: 978-0-12-443710-4<br />
<h3>Zunanje povezave</h3><br />
[http://www.ncbi.nlm.nih.gov/pubmed/11839807]<br />
[http://www.springer.com/biomed/cancer/book/978-0-387-33826-2]<br />
[http://www.elsevier.com/wps/find/bookdescription.cws_home/703167/description#description]<br />
[[Category:LEX]]</div>
Martin Gramc