https://wiki.fkkt.uni-lj.si/index.php?action=history&feed=atom&title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_%2F_Jennsen_%28Ad26%29
Značilnosti cepiva proizvajalca Johnson&Johnson / Jennsen (Ad26) - Revision history
2026-05-30T17:47:41Z
Revision history for this page on the wiki
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https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18241&oldid=prev
Mirsad93 at 18:58, 6 April 2021
2021-04-06T18:58:11Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 18:58, 6 April 2021</td>
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<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Johnson & Johnson / Jennsen (JNJ-78436735 ali Ad26.COV2.S) je enodozno virusno vektorsko cepivo na osnovi človeškega adenovirusa 26, ki je bilo spremenjeno tako, da vsebuje gen za izdelavo koničastega proteina virusa SARS-CoV-2. Virusni vektor, ki izraža koničasti protein (''ang. spike protein'') SARS-CoV-2 (S), je v stabilizirani konformaciji. Stabilizirana različica koničastega proteina vključuje dve mutaciji, pri katerih se običajne aminokisline nadomestijo s prolini (K986P, V987P) in se uvede mutacija mesta cepitve (R682S, R685G).</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Johnson & Johnson / Jennsen (JNJ-78436735 ali Ad26.COV2.S) je enodozno virusno vektorsko cepivo na osnovi človeškega adenovirusa 26, ki je bilo spremenjeno tako, da vsebuje gen za izdelavo koničastega proteina virusa SARS-CoV-2. Virusni vektor, ki izraža koničasti protein (''ang. spike protein'') SARS-CoV-2 (S), je v stabilizirani konformaciji. Stabilizirana različica koničastega proteina vključuje dve mutaciji, pri katerih se običajne aminokisline nadomestijo s prolini (K986P, V987P) in se uvede mutacija mesta cepitve <ins style="font-weight: bold; text-decoration: none;">furina </ins>(R682S, R685G).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Po injiciranju cepiva v telo se adenovirusi priklopijo na beljakovine na površini celic. Celica virus zajame v mehurček in ga potegne vase. Ko vstopi v celico, adenovirus pobegne iz endosoma in potuje do jedra ter vanj potisne svojo DNA. To stori zato ker adenovirus ni sposoben replikacije, medtem ko lahko celica prebere zapis za protein in ta zapis kopira v mRNA. Preko mehanizma translacije celica potem začne sintetizirati koničaste proteine, ki se preselijo na njeno površino. Štrleče konice in drobce proteinov lahko potem prepozna imunski sistem. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Po injiciranju cepiva v telo se adenovirusi priklopijo na beljakovine na površini celic. Celica virus zajame v mehurček in ga potegne vase. Ko vstopi v celico, adenovirus pobegne iz endosoma in potuje do jedra ter vanj potisne svojo DNA. To stori zato ker adenovirus ni sposoben replikacije, medtem ko lahko celica prebere zapis za protein in ta zapis kopira v mRNA. Preko mehanizma translacije celica potem začne sintetizirati koničaste proteine, ki se preselijo na njeno površino. Štrleče konice in drobce proteinov lahko potem prepozna imunski sistem. </div></td></tr>
</table>
Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18238&oldid=prev
Mirsad93 at 16:32, 6 April 2021
2021-04-06T16:32:52Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:32, 6 April 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico<del style="font-weight: bold; text-decoration: none;">. Imunost </del>se razvije dva tedna po cepljenju. Cepivo je spravljeno v hladilniku na temperaturi med 2°C in 8°C. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico<ins style="font-weight: bold; text-decoration: none;">, imunost </ins>se razvije dva tedna po cepljenju. Cepivo je spravljeno v hladilniku na temperaturi med 2°C in 8°C. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td></tr>
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Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18237&oldid=prev
Mirsad93 at 16:31, 6 April 2021
2021-04-06T16:31:25Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:31, 6 April 2021</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8">Line 8:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico<ins style="font-weight: bold; text-decoration: none;">. Imunost se razvije dva tedna po cepljenju. Cepivo je spravljeno v hladilniku na temperaturi med 2°C in 8°C</ins>. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td></tr>
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Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18236&oldid=prev
Mirsad93 at 16:12, 6 April 2021
2021-04-06T16:12:26Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:12, 6 April 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>9. Johnson & Johnson COVID-19 Vaccine Authorized by U.S. FDA For Emergency Use - First Single-Shot Vaccine in Fight Against Global Pandemic https://www.jnj.com/johnson-johnson-covid-19-vaccine-authorized-by-u-s-fda-for-emergency-usefirst-single-shot-vaccine-in-fight-against-global-pandemic</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>9. Johnson & Johnson COVID-19 Vaccine Authorized by U.S. FDA For Emergency Use - First Single-Shot Vaccine in Fight Against Global Pandemic https://www.jnj.com/johnson-johnson-covid-19-vaccine-authorized-by-u-s-fda-for-emergency-usefirst-single-shot-vaccine-in-fight-against-global-pandemic</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">10. PER.C6 Cell Lines https://www.gmp-creativebiolabs.com/per-c6-cell-lines_74.htm</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">11. COVID vaccine: EU regulators approve Johnson & Johnson shot https://www.dw.com/en/covid-vaccine-eu-regulators-approve-johnson-johnson-shot/a-56834858</ins></div></td></tr>
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Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18235&oldid=prev
Mirsad93: /* Viri */
2021-04-06T16:09:14Z
<p><span class="autocomment">Viri</span></p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:09, 6 April 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>6. Sadoff J, L.G., Shukarev G. ''et. al.'' Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med. 2021 Jan 13:NEJMoa2034201. doi: 10.1056/NEJMoa2034201. Epub ahead of print. PMID: 33440088; PMCID: PMC7821985.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>6. Sadoff J, L.G., Shukarev G. ''et. al.'' Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med. 2021 Jan 13:NEJMoa2034201. doi: 10.1056/NEJMoa2034201. Epub ahead of print. PMID: 33440088; PMCID: PMC7821985.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">7. Janssen Investigational COVID-19 Vaccine: Interim Analysis of Phase 3 Clinical Data Released https://www.nih.gov/news-events/news-releases/janssen-investigational-covid-19-vaccine-interim-analysis-phase-3-clinical-data-released</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">8. FACT SHEET FOR RECIPIENTS AND CAREGIVERS’ EMERGENCY USE AUTHORIZATION (EUA) OF THE JANSSEN COVID-19 VACCINE TO PREVENT CORONAVIRUS DISEASE 2019 (COVID-19) IN INDIVIDUALS 18 YEARS OF AGE AND OLDER https://www.fda.gov/media/146305/download</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">9. Johnson & Johnson COVID-19 Vaccine Authorized by U.S. FDA For Emergency Use - First Single-Shot Vaccine in Fight Against Global Pandemic https://www.jnj.com/johnson-johnson-covid-19-vaccine-authorized-by-u-s-fda-for-emergency-usefirst-single-shot-vaccine-in-fight-against-global-pandemic</ins></div></td></tr>
</table>
Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18234&oldid=prev
Mirsad93 at 15:58, 6 April 2021
2021-04-06T15:58:03Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:58, 6 April 2021</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l12">Line 12:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>1. Custers, J., Kim, D. et. al. Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment. Vaccine. (2020). 10.1016/j.vaccine.2020.09.018.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>1. Custers, J., Kim, D. <ins style="font-weight: bold; text-decoration: none;">''</ins>et. al.<ins style="font-weight: bold; text-decoration: none;">'' </ins>Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment. Vaccine. (2020). 10.1016/j.vaccine.2020.09.018.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>2. Tostanoski, L., Wegmann, F. et. al. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nature Medicine. (2020). 26. 1-7. 10.1038/s41591-020-1070-6.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>2. Tostanoski, L., Wegmann, F. <ins style="font-weight: bold; text-decoration: none;">''</ins>et. al.<ins style="font-weight: bold; text-decoration: none;">'' </ins>Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nature Medicine. (2020). 26. 1-7. 10.1038/s41591-020-1070-6.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>3. Bos R., Rutten L. et. al. Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses. NPJ Vaccines. 2020 Sep 28;5:91. doi: 10.1038/s41541-020-00243-x. PMID: 33083026; PMCID: PMC7522255.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>3. Bos R., Rutten L. <ins style="font-weight: bold; text-decoration: none;">''</ins>et. al.<ins style="font-weight: bold; text-decoration: none;">'' </ins>Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses. NPJ Vaccines. 2020 Sep 28;5:91. doi: 10.1038/s41541-020-00243-x. PMID: 33083026; PMCID: PMC7522255.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>4. Abbink, P.L., Angelique, E. et. al. Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D. Journal of virology. (2007). 81. 4654-63. 10.1128/JVI.02696-06.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>4. Abbink, P.L., Angelique, E. <ins style="font-weight: bold; text-decoration: none;">''</ins>et. al.<ins style="font-weight: bold; text-decoration: none;">'' </ins>Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D. Journal of virology. (2007). 81. 4654-63. 10.1128/JVI.02696-06.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>5. Mercado, N.B., Zahn, R., Wegmann, F. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586, 583–588 (2020). https://doi.org/10.1038/s41586-020-2607-z.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>5. Mercado, N.B., Zahn, R., Wegmann, F. <ins style="font-weight: bold; text-decoration: none;">''</ins>et al.<ins style="font-weight: bold; text-decoration: none;">'' </ins>Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586, 583–588 (2020). https://doi.org/10.1038/s41586-020-2607-z.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>6. Sadoff J, L.G., Shukarev G. et. al. Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med. 2021 Jan 13:NEJMoa2034201. doi: 10.1056/NEJMoa2034201. Epub ahead of print. PMID: 33440088; PMCID: PMC7821985.</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>6. Sadoff J, L.G., Shukarev G. <ins style="font-weight: bold; text-decoration: none;">''</ins>et. al.<ins style="font-weight: bold; text-decoration: none;">'' </ins>Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med. 2021 Jan 13:NEJMoa2034201. doi: 10.1056/NEJMoa2034201. Epub ahead of print. PMID: 33440088; PMCID: PMC7821985.</div></td></tr>
</table>
Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18233&oldid=prev
Mirsad93 at 15:56, 6 April 2021
2021-04-06T15:56:55Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<col class="diff-marker" />
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<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:56, 6 April 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>1. Custers, J., Kim, D. et. al. Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment. Vaccine. (2020). 10.1016/j.vaccine.2020.09.018.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>1. Custers, J., Kim, D. et. al. Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment. Vaccine. (2020). 10.1016/j.vaccine.2020.09.018.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>2. Tostanoski, L., Wegmann, F. et. al. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nature Medicine. (2020). 26. 1-7. 10.1038/s41591-020-1070-6.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>2. Tostanoski, L., Wegmann, F. et. al. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nature Medicine. (2020). 26. 1-7. 10.1038/s41591-020-1070-6.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3. Bos R., Rutten L. et. al. Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses. NPJ Vaccines. 2020 Sep 28;5:91. doi: 10.1038/s41541-020-00243-x. PMID: 33083026; PMCID: PMC7522255.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>3. Bos R., Rutten L. et. al. Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses. NPJ Vaccines. 2020 Sep 28;5:91. doi: 10.1038/s41541-020-00243-x. PMID: 33083026; PMCID: PMC7522255.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4. Abbink, P.L., Angelique, E. et. al. Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D. Journal of virology. (2007). 81. 4654-63. 10.1128/JVI.02696-06.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>4. Abbink, P.L., Angelique, E. et. al. Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D. Journal of virology. (2007). 81. 4654-63. 10.1128/JVI.02696-06.</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>5. Mercado, N.B., Zahn, R., Wegmann, F. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586, 583–588 (2020). https://doi.org/10.1038/s41586-020-2607-z</div></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>5. Mercado, N.B., Zahn, R., Wegmann, F. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586, 583–588 (2020). https://doi.org/10.1038/s41586-020-2607-z<ins style="font-weight: bold; text-decoration: none;">.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>6. Sadoff J, L.G., Shukarev G. et. al. Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med. 2021 Jan 13:NEJMoa2034201. doi: 10.1056/NEJMoa2034201. Epub ahead of print. PMID: 33440088; PMCID: PMC7821985.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>6. Sadoff J, L.G., Shukarev G. et. al. Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med. 2021 Jan 13:NEJMoa2034201. doi: 10.1056/NEJMoa2034201. Epub ahead of print. PMID: 33440088; PMCID: PMC7821985.</div></td></tr>
</table>
Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18232&oldid=prev
Mirsad93 at 15:56, 6 April 2021
2021-04-06T15:56:10Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:56, 6 April 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">1. Custers, J., Kim, D. et. al. Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment. Vaccine. (2020). 10.1016/j.vaccine.2020.09.018.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">2. Tostanoski, L., Wegmann, F. et. al. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters. Nature Medicine. (2020). 26. 1-7. 10.1038/s41591-020-1070-6.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">3. Bos R., Rutten L. et. al. Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses. NPJ Vaccines. 2020 Sep 28;5:91. doi: 10.1038/s41541-020-00243-x. PMID: 33083026; PMCID: PMC7522255.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">4. Abbink, P.L., Angelique, E. et. al. Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D. Journal of virology. (2007). 81. 4654-63. 10.1128/JVI.02696-06.</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">5. Mercado, N.B., Zahn, R., Wegmann, F. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586, 583–588 (2020). https://doi.org/10.1038/s41586-020-2607-z</ins></div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">6. Sadoff J, L.G., Shukarev G. et. al. Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine. N Engl J Med. 2021 Jan 13:NEJMoa2034201. doi: 10.1056/NEJMoa2034201. Epub ahead of print. PMID: 33440088; PMCID: PMC7821985.</ins></div></td></tr>
</table>
Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18231&oldid=prev
Mirsad93 at 15:32, 6 April 2021
2021-04-06T15:32:19Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:32, 6 April 2021</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td></tr>
</table>
Mirsad93
https://wiki.fkkt.uni-lj.si/index.php?title=Zna%C4%8Dilnosti_cepiva_proizvajalca_Johnson%26Johnson_/_Jennsen_(Ad26)&diff=18230&oldid=prev
Mirsad93 at 15:28, 6 April 2021
2021-04-06T15:28:44Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:28, 6 April 2021</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1">Line 1:</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Johnson & Johnson / Jennsen (JNJ-78436735 ali Ad26.COV2.S) je enodozno virusno vektorsko cepivo na osnovi človeškega adenovirusa 26, ki je bilo spremenjeno tako, da vsebuje gen za izdelavo koničastega proteina virusa SARS-CoV-2. Virusni vektor, ki izraža koničasti protein (''ang. spike protein'') SARS-CoV-2 (S), je v stabilizirani konformaciji. Stabilizirana različica koničastega proteina vključuje dve mutaciji, pri katerih se običajne aminokisline nadomestijo s prolini (K986P, V987P) in se uvede mutacija mesta cepitve (R682S, R685G).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Johnson & Johnson / Jennsen (JNJ-78436735 ali Ad26.COV2.S) je enodozno virusno vektorsko cepivo na osnovi človeškega adenovirusa 26, ki je bilo spremenjeno tako, da vsebuje gen za izdelavo koničastega proteina virusa SARS-CoV-2. Virusni vektor, ki izraža koničasti protein (''ang. spike protein'') SARS-CoV-2 (S), je v stabilizirani konformaciji. Stabilizirana različica koničastega proteina vključuje dve mutaciji, pri katerih se običajne aminokisline nadomestijo s prolini (K986P, V987P) in se uvede mutacija mesta cepitve (R682S, R685G).</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Po injiciranju cepiva v telo se adenovirusi priklopijo na beljakovine na površini celic. Celica virus zajame v mehurček in ga potegne vase. Ko vstopi v celico, adenovirus pobegne iz endosoma in potuje do jedra ter vanj potisne svojo DNA. To stori zato ker adenovirus ni sposoben replikacije, medtem ko lahko celica prebere zapis za protein in ta zapis kopira v mRNA. Preko mehanizma translacije celica potem začne sintetizirati koničaste proteine, ki se preselijo na njeno površino. Štrleče konice in drobce proteinov lahko potem prepozna imunski sistem. </div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Po injiciranju cepiva v telo se adenovirusi priklopijo na beljakovine na površini celic. Celica virus zajame v mehurček in ga potegne vase. Ko vstopi v celico, adenovirus pobegne iz endosoma in potuje do jedra ter vanj potisne svojo DNA. To stori zato ker adenovirus ni sposoben replikacije, medtem ko lahko celica prebere zapis za protein in ta zapis kopira v mRNA. Preko mehanizma translacije celica potem začne sintetizirati koničaste proteine, ki se preselijo na njeno površino. Štrleče konice in drobce proteinov lahko potem prepozna imunski sistem. </div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Genomi adenovirusa so linearne, nesegmentirane dvoverižne molekule DNA z obrnjenimi zaporedji končnih ponovitev (ITR) na obeh koncih. Vektorski sistem za razmnoževanje Ad26 je sestavljen iz adapterskega plazmida in kozmida. Adapterski plazmid vsebuje levi konec genoma, ki vsebuje levi ITR in signal za pakiranje. Vsebuje tudi kaseto za ekspresijo transgena (stabilizirani koničasti protein S) namesto regije E1 in fragment 2.5 kb, ki leži navzdol od regije E1, da se omogoči homologna rekombinacija s kozmidom. Kosmid vsebuje večino genoma Ad z izbrisom regije E3 in spremenjenim odprtim bralnim okvirom E4 6 (E5orf6).</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Genomi adenovirusa so linearne, nesegmentirane dvoverižne molekule DNA z obrnjenimi zaporedji končnih ponovitev (ITR) na obeh koncih. Vektorski sistem za razmnoževanje Ad26 je sestavljen iz adapterskega plazmida in kozmida. Adapterski plazmid vsebuje levi konec genoma, ki vsebuje levi ITR in signal za pakiranje. Vsebuje tudi kaseto za ekspresijo transgena (stabilizirani koničasti protein S) namesto regije E1 in fragment 2.5 kb, ki leži navzdol od regije E1, da se omogoči homologna rekombinacija s kozmidom. Kosmid vsebuje večino genoma Ad z izbrisom regije E3 in spremenjenim odprtim bralnim okvirom E4 6 (E5orf6).</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepiva na osnovi vektorjev Ad26 izdelujejo z uporabo celične linije človeških embrionalnih mrežničnih celic (PER.C6), neprekinjene človeške celične linije, ki lahko podpira izdelavo adenovirusnih vektorjev, ki niso sposobni replikacije.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepiva na osnovi vektorjev Ad26 izdelujejo z uporabo celične linije človeških embrionalnih mrežničnih celic (PER.C6), neprekinjene človeške celične linije, ki lahko podpira izdelavo adenovirusnih vektorjev, ki niso sposobni replikacije.</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"></ins></div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Cepivo Janssen COVID-19 vključuje naslednje sestavine: rekombinantni adenovirus tipa 26, ki ni sposoben replikacije in ki izraža beljakovino SARS-CoV-2, monohidrat citronske kisline, trinatrijev citrat dihidrat, etanol, 2-hidroksipropil-β-ciklodekstrin (HBCD), polisorbat-80, natrijev klorid.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>Klinična preskušanja so pokazala, da je imel en odmerek cepiva v ZDA 72-odstotno stopnjo učinkovitosti in nižjo učinkovitost (66% Latinska Amerika, Južna Afrika 57%) v državah, kjer so razširjene bolj nalezljive različice. Cepivo ima 85-odstotno učinkovitost pri zaščiti pred hospitalizacijo v vseh geografskih regijah. Cepivo se daje v nadlaktno mišico. Najpogostejši neželeni učinki, ki se običajno začnejo v enem ali dveh dneh po prejemu cepiva, so: rdečica, oteklina, utrujenost, glavobol, bolečine v mišicah. Cepivo so ZDA odobrile za nujno uporabo 27. februarja in EU 11. marca 2021.</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== '''Viri''' ==</div></td></tr>
</table>
Mirsad93