RNA vezavni proteini

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Uvod

Struktura in funkcija

Ohranjanje genomske stabilnosti

Odziv na poškodbe DNA

Nadzor RNA

Ohranjanje dolžine telomer

Bolezni

ALS

Rak

Zaključek

Viri

  • A. T. Aborode, O. A. Abass, S. Nasiru, M. U. Eigbobo, S. Nefishatu, A. Idowu, Z. Tiamiyu, A. A. Awaji, N. Idowu, B. R. Busayo, idr.: RNA binding proteins (RBPs) on genetic stability and diseases. Glob. Med. Genet. 2025, 12, 100032. DOI: 10.1016/j.gmg.2024.100032

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[2] S. A. Wolfe, L. Nekludova, C. O. Pabo: DNA Recognition by Cys2 His2 Zinc Finger Proteins. Annu. Rev. Biophys. Biomol. Struct. 2000, 29, 183–212. DOI: 10.1146/annurev.biophys.29.1.183

[3] D. S. M. Ottoz, L. E. Berchowitz: The role of disorder in RNA binding affinity and specificity. Open Biol. 2020, 10, 200328. DOI: 10.1098/rsob.200328

[4] B. Mikolaskova, M. Jurcik, I. Cipakova, M. Kretova, M. Chovanec, L. Cipak: Maintenance of genome stability: the unifying role of interconnections between the DNA damage response and RNA-processing pathways. Curr. Genet. 2018, 64, 971–983. DOI: 10.1007/s00294-018-0819-7

[5] M. V. Sukhanova, A. S. Singatulina, D. Pastré, O. I. Lavrik: Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA. Int. J. Mol. Sci. 2020, 21, 7020. DOI: 10.3390/ijms21197020

[6] T. Kurosaki, M. W. Popp, L. E. Maquat: Quality and quantity control of gene expression by nonsense-mediated mRNA decay. Nat. Rev. Mol. Cell Biol. 2019, 20, 406–420. DOI: 10.1038/s41580-019-0126-2

[7] A. L. Karamyshev, Z. N. Karamysheva: Lost in Translation: Ribosome-Associated mRNA and Protein Quality Controls. Front. Genet. 2018, 9, 431. DOI: 10.3389/fgene.2018.00431

[8] S. Redon, I. Zemp, J. Lingner: A three-state model for the regulation of telomerase by TERRA and hnRNPA1. Nucleic Acids Res. 2013, 41, 9117–9128. DOI: 10.1093/nar/gkt695

[9] E. Petti, V. Buemi, A. Zappone, O. Schillaci, P. V. Broccia, R. Dinami, S. Matteoni, R. Benetti, S. Schoeftner: SFPQ and NONO suppress RNA:DNA-hybrid-related telomere instability. Nat. Commun. 2019, 10, 1001. DOI: 10.1038/s41467-019-08863-1